对乳酸菌CRISPR—Cas系统(即:成簇的、规律间隔的短回文重复序列及相关Cas蛋白系统)抗噬菌体机制以及噬菌体进化出的相应免疫逃逸机制进行综述,旨为进一步研究噬菌体抗性乳酸菌发酵剂奠定基础。
The aim of this paper is to describe the anti-phage mechanism of CR1SPR-Cas system and the mechanisms for phages to evadeCRISPR-Cas systems, which may provide a certain theoretical support to the construction of anti-phage strains.