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中文摘要：
细胞膜是蛋白质、核酸及药物分子进入细胞的主要生物学屏障。近年来的研究发现细胞穿膜肽（cellpenetrating peptides,CPPs）能够有效地将小分子药物、蛋白质、肽类、核酸片段以及纳米载体（如脂质体、聚合物胶束、无机纳米粒等）转运穿过细胞膜。本文就细胞穿膜肽的分类及其在介导小分子药物、蛋白质及多肽、核酸和纳米载体特别是＂智能＂纳米载体等的转运入胞作用进行了讨论。
英文摘要：
Cell membrane serves as the natural barrier. Cell-penetrating peptides（CPPs） have been a powerful vehicle for the intracellular delivery of a large variety of cargoes cross the cell membrane. The efficiency of intracellular delivery of drugs, proteins, peptides and nucleic acid, as well as various nanoparticulate pharmaceutical carriers（e.g., liposomes, polymeric micelles and inorganic nanoparticles） has been demonstrated both in vitro and in vivo. This review focuses on the CPPs-based strategy for intracellular delivery of small molecule drugs, proteins, peptides, nucleic acid and CPP-modified nanocarriers.
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