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中文摘要：
目的 探讨纳米锌材料对小鼠血清生化指标的影响。方法 小鼠以5g／（kg·bw）剂量的纳米或微米粒径锌粉一次经口灌胃，14d后处死取血清，观察血清常规生化指标的变化。结果 纳米锌粉组小鼠血清除乳酸脱氢酶（LDH）和α-羟丁酸脱氢酶（HBDH）与对照组比较有明显升高外（P〈0．05），其余血清生化指标与对照组相比较差异无统计学意义（P〉0．05）；而微米锌粉组小鼠血清LDH、HBDH、丙氨酸氨基移换酶（ALT）、碱性磷酸酶（ALP）、假性胆碱脂酶（ChE）等多个生化指标均比对照组有明显升高（P〈0．05）；纳米锌粉组小鼠血清LDH、HBDH、ChE等生化指标水平明显低于微米锌粉组（P〉0、05）。结论 纳米级锌粉对小鼠血清生化指标的影响与微米锌粉有所不同。
英文摘要：
Objective To explore the effect of Nano- zinc powder on mice serum biochemical indexes. Methods The mice were treated by one single oral dose of nano - zinc or micron - zinc powder at 5 g/（ kg·bw）. A/terl4 days, the mice were sacrificed and the serum were collected for biochemical analysis. Results In Nano - zinc group, only the serum LDH, HBDH were obviously higher than that in control group（ P 〉 0.05）, but in micron-zinc powder group, the serum LDH, HBDH, ALT,ALP, CHE, LAP, TP, ALB, AST, UA, BUN, Ca, P, TG were higher significantly than that in control group（P 〉 0.05 ）. The serum LDH, HBDH, ChE, LAP, TP, ALB, Ca of Nano - zinc group were lower than those in micron - zinc powder group significantly（P 〉 0.05）. Conclusion In general the Nano - zinc has difference effect on mice biochemical indexes as compared with the micron zinc powder.
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