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纳米氧化物对斑马鱼胚胎孵化率的影响
  • 期刊名称：中国环境科学, 2009, 29(1): 53-57
  • 时间：0
  • 分类：X503.2[环境科学与工程—环境工程]
  • 作者机构：[1]安徽理工大学地球与环境学院,安徽淮南232001, [2]中国科学院高能物理研究所,纳米生物效应与安全性联合实验室,北京100049
  • 相关基金：国家自然科学基金资助项目（10490180,10505024,20707027）;国家“973”项目（2006CB705605）;致谢：衷心感谢北京大学生命科学学院遗传发育中心斑马鱼实验室在斑马鱼养殖和孵化方面提供的诸多帮助.
  • 相关项目：碳纳米物质在模拟水生态系统中的行为
关键词： 纳米氧化物, 斑马鱼胚胎, 毒性, 孵化率, nanooxide, zebrafishembryo, toxicity, hatching rate
中文摘要：

为评价纳米氧化物的水生态毒理效应，以模式生物斑马鱼胚胎为研究对象，观察了纳米ZnO、纳米TiO2、纳米Fe2O3、纳米Fe3O4和纳米SiO2对其96h孵化率的影响.结果表明，纳米氧化物毒性与其成分有很大关系.纳米ZnO对斑马鱼胚胎孵化抑制作用明显，毒性较大，且其毒性与浓度之间存在一定的剂量-效应关系；在低浓度时，纳米ZnO抑制胚胎孵化的效应较等浓度Zn^2＋强，说明纳米ZnO特殊理化性质发挥了一定作用.纳米Fe2O3在低浓度下不影响胚胎孵化率，而在高浓度下抑制胚胎孵化.纳米TiO2、纳米Fe3O4、和纳米SiO2对斑马鱼胚胎96h孵化率没有明显影响.

英文摘要：

The ecotoxicological impacts of nanooxides （nano-ZnO, nano-TiO2, nano-Fe2O3, nano-Fe3O4 and nano-SiO2） were studied by observing the hatching rate of zebrafish embryos at 96h. Different nanooxides had different effects on hatching rate of zebrafish embryos, suggesting that the toxicity was much related to their own components. Nano-ZnO decreased the hatching rate of embryos in a concentration-dependent way and had a higher toxicity. At low concentration, the inhibition of nano-ZnO on embryo hatching was more severe than Zn^2＋ of the same concentration, probably due to its own special properties. The hatching rate of zebrafish embryos did not affected by nano-Fe2O3 at low conentration, but was inhibited at high concentration. Other nanooxides, including nano-TiO2, nano-Fe3O4 and nano-SiO2, had little effect on embryo hatching.

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