中文摘要：

目的研究血清抗核小体抗体（AnuA）水平与狼疮肾炎（LN）病理类型及其活动性的相关性。方法选取110例系统性红斑狼疮（SLE）患者（狼疮肾炎34例进行肾脏病理,非狼疮肾炎76例）作为研究对象,同时选取健康体检者30例作为正常对照组,用酶联免疫吸附法（ELISA）检测血清中的AnuA水平,并与LN病理类型及活动性指标进行相关性分析。结果 SLE组中血清AnuA水平（107.2±86.5）RU·mL-1显著高于正常对照组（17.4±14.0）RU·mL-1（t=8.37,P〈0.05）;狼疮肾炎组血清AnuA水平（115.0±87.0）RU·mL-1明显高于非狼疮肾炎组（68.1±49.3）RU·mL-1（t=4.28,P〈0.05）;各肾脏病理类型的血清AnuA水平差异有统计学意义,IV型III型LN患者血清AnuA水平高于V型II型,V型又高于II型（P〈0.05）。血清AnuA与活动指数（AI）呈正相关（r=0.69,P〈0.05）,与慢性指数（CI）无显著相关性。血清AnuA水平与肾脏病变临床活动度的关系表现为：血清AnuA水平由高向低依次为肾炎复发组、尿蛋白复发组、部分缓解组、持续活动组和完全缓解组;肾炎复发组和尿蛋白复发组显著高于其它活动度组（P〈0.05）,肾炎复发组又显著高于尿蛋白复发组（P〈0.05）。结论 AnuA水平与SLE患者肾脏损害显著相关,不同肾脏病理类型的血清AnuA水平表达有差异,可用于评估临床治疗及预后。

英文摘要：

Objective To study the relationship between the lupus nephritis （LN） pathological type, activity and serum anti - uucleosome antibody （AnuA）. Methods 110 patients with system lupus erythematosus （SLE） were studied, including 34 lupus nephri- tis patients who were diagnosed by renal pathology and the other 76 cases without LN. Meanwhile ,30 healthy physical examine in our hos- pital were taken as normal controls. The AnuA in the serum of the SLE patients and healthy controls was examined by enzyme - linked immunosorbent assay （ ELISA）, and the relationship between LN pathological type, activity and AnuA were analyzed. Results The aver- age serum AnuA level （107 _＋ 86） RU/ml of SLE group was significantly higher than that of the control group （17 ~ 14 ） RU/ml （t = 8.37 ,P 〈 0.05 ） ;The average serum AnuA level （115 _＋ 87 ） RU/ml of the lupus nephritis patients was significantly higher than that of the patients without LN （68 ± 49 ） RU/ml （t = 4. 287, P 〈 0.05 ） ;There were statistical differences in the serum AnuA levels between the various LN pathologieal types. The AnuA levels in type IV and HI LN were higher than that in the type V and 1I , and the type V LN was higher than type II （ P 〈 0.05 ）. There was a positive eorrelation between serum AnuA level and activity index （AI） , and there was no significant correlation of AnuA and chronic index （CI）. The relationship between serum AnuA levels and kidney disease clinical activ- ity from high to low in the order was ： renal flares group, urine protein recurrence group, partial remission group, continuously active group and complete remission group. The relationship in renal flares group and urine protein recurrence group was higher than that in other groups （ P 〈 0.05 ） , and the renal flares group was higher than urine protein reeurrenee group （ P 〈 0.05 ）. Conclusion Serum AnuA level is significantly correlated with renal damage of SLE patients, and the differences of serum AnuA among va