中文摘要：

这研究分析了老鼠抗体和老鼠蛋白质认出的非自我 T 房间 epitopes 的氨基酸顺序类似。用顺序排列，我们仅仅发现了那 1 108 epitopes 中的 8 个高度类似于老鼠蛋白质序列。结果证明非自我 T 房间 epitopes 不是类似的或有小类似到老鼠蛋白质序列。而且，考察相关文学，我们也发现八 epitopes 将在一些特别环境触发有免疫力的回答，它被 T 房间处于正常状况忽略。结果不建议那或低类似的肽疫苗能减少跨反应的担保的机会并且提高抗原特定的有免疫力的反应到疫苗。

英文摘要：

This research analyzed amino acid sequence similarity between non-self T cell epitopes recognized by mouse antibodies and mouse proteins. Using sequence alignment,we found that only 8 of 1 108 epitopes are highly similar to mouse protein sequences. The result shows that non-self T cell epitopes are not similar or have little similarity to mouse protein sequences. Furthermore,reviewing the related literature,we also found that the eight epitopes would trigger immune responses in some particular environment,which are ignored by T cells in normal condition. The result suggests that no or low-similarity peptide vaccines can reduce the chance of collateral cross-reactions and enhance the antigen-specific immune response to vaccine.