中文摘要：

黄曲霉毒素B1（aflatoxin B1,AFB1）作为黄曲霉主要的代谢产物之一,进入动物体内后主要影响动物的抗氧化系统和免疫系统,是霉菌毒素中主要的致病致癌物质。AFB1代谢主要存在于动物肝脏中,肝微粒体中的细胞色素酶P450（cytochrome P450,CYP450s）是动物体内参与多种药物及毒物代谢的主要酶类。细胞色素酶P3A4（cytochrome P3A4,CYP3A4）是CYP450s的同工酶,主要参与肝脏内AFB1的代谢。进入动物机体内的AFB1经CYP3A4代谢的产物一部分与DNA、RNA结合产生致毒效应;另一部分在谷胱甘肽过氧化物酶（GSH-Px）、谷胱甘肽硫转移酶（GST）等作用下进入血液和尿液,发生解毒效应。在饲料中添加抗氧化剂对于缓解AFB1的毒性有良好效果。饲料中添加一些天然物质或化学成分可以适当抑制肝脏内CYP3A4的活性,对于研究AFB1对机体的损伤具有重要意义,还可为开发新的饲料添加剂提供新思路。

英文摘要：

Aflatoxin B1（AFB1） is one of the metabolites of aflatoxin,which mainly affects the antioxidant systems and the immune systems in vivo as the main pathogenic carcinogenic substances in an organism.AFB1 metabolism was mainly found in animal liver,and the cytochrome P450（CYP450s） in liver microsomal involved in a variety of drug and toxicant metabolism.Cytochrome CYP3A4（CYP3A4） involved in the metabolism of AFB1 as the isozyme of CYP450 in the liver.AFB1 ingested by an animal combines with DNA and RNA and produces toxic effects,and another part of AFB1 metabolizes with glutathione peroxidase and glutathione S-transferase enzymes and then goes into blood and urine,which acts as detoxification effect.Adding antioxidants in feeds has a positive effect on relieving AFB1 toxicity.Another way to study AFB1 damage is to add some natural or chemical ingredients in feeds to act as the inhibition of CYP3A4 in the liver,which will provide a new approach to the development of feed additives.