中文摘要：

目的：观察油酸诱导急性呼吸窘迫综合征（ARDS）大鼠心脏局部 RAS的影响及心功能的变化。方法雄性SD大鼠36只，随机分成假手术组和造模组，每组18只，各组又按造模成功后1h、2h和4h分为a、b、c3个亚组。（1）假手术组（S组）：仅进行气管切开插管和右颈总动脉穿刺置管，尾静脉注射生理盐水0．15 mL/kg ；（2）造模组（C组）：尾静脉注射油酸0．15 mL/kg ，建立油酸诱导的大鼠A RDS模型。每组有效检测与活杀取材的大鼠均为18只。结果与S组比较，C组L V-EDP、AngⅡ含量及Renin活性均明显升高（P＜0．05），LVSP、±LVdp/dtmax明显下降。结论 ARDS可致大鼠心肌损害、心功能降低，同时激活心脏局部RAS。

英文摘要：

Objective To observe the relationship of the cardiac function and the level of local RAS in acute respiratory distress syndrome （ARDS） rats induced by oleic acid .Methods Sprague-Daw-ley rats were randomly divided into two groups .Group S ：Control Group （only tracheal intubation ,the right carotid artery catheterization ,and tail vein injection of normal saline 0 .15 mL/kg .n=18）;Group C （ ARDS group：the ARDS model of rats induced by tail vein injection of oleic acid 0 .15 mL/kg ,n=18） .Two groups were randomly divided into 3 subgroups respectively by 1 h ,2 h and 4 h after the modeling ,and there were 6 rats in each group with effective detection and killed alive for materials .Recording the left ventricular systolic pressure （LVSP） ,maximum rising and falling rate of left intraventricular pressure （ ± LVdp/dtmax） ,and left ventricular end-diastolic pressure （LVEDP） at each time point .AngiotensinⅡ（ AngⅡ） concentration in myocardial tissue and renin activity level （ Renin ） were be detected respectively . Results In ARDS rats ,LVSP ,LVEDP ,± LVdp/dtmax ,Ang Ⅱcontent and Renin activity were high-er than control group with significant difference （P〈0 .05） .ConclusionARDS could induce myocardial damage ,decrease cardiac function and activation of cardiac local RAS in rats ..