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中文摘要：
微型全分析系统（μTAS）的最终目标是把化学分析中的采样、预处理、分离及检测等操作单元集成于自动化、便携式的微型智能分析仪器之中．作为μTAS核心的微流控芯片在过去的十年中发展迅速．但多数微流控芯片功能依然比较单一，主要集中于芯片毛细管电泳（Chip-based capillary electrophoresis，CCE）分离分析．近年来，有关试样预处理微流控芯片的报道较多．比较成功地将试样预处理与毛细管电泳分离集成于一体的联用芯片主要涉及集成化在线酶解、固相萃取和膜富集等．将液液萃取与毛细管电泳集成于一体的联用芯片尚未见报道．
英文摘要：
This article presents the designing and fabrication of a microfluoidic chip with an integrated supported-liquid-membrane extraction-back-extraction and chip-based capillary electrophoresis system （SLMEBE-CCE）. A 3-dimensional channel network for the SLMEBE-CCE system was fabricated with a four-layer glass/PTFE-membrane hybrid structure. With a gravity pump for sample and back-extraction solution delivery and a multi-channel high-voltage supply for CCE separation, the microchip with the coupled SLMEBE-CCE system was demonstrated by the pre-concentration, separation and detection of a mixed solution of fluorescein and butyl-rhodamine B. Compared to chip-based CCE without SLMEBE, the developed SLMEBE-CCE system produced a 7-fold increase in the signal of the model analyte of fluorescein and a 4-fold decrease in the signal of the model co-existing compound of butyl-rhodamine B.
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