中文摘要：

粗糙脉孢菌是一种重要的模式生物，在遗传调节机制、昼夜节律运行以及真菌光应答反应研究中起重要的作用．本综述主要介绍粗糙脉孢菌光受体WC-1和VVD的结构与功能，以及它们参与调节昼夜节律和光适应机制方面的研究进展．在该真菌中，所有已知的光应答反应都受蓝光调节，由光受体WC-1和VVD介导．WC-1是该真菌的转录因子，介导最初的光反应过程，产生VVD等多种光反应蛋白，而VVD通过负反馈机制抑制WC-1的转录作用．此外，vvd基因已经用于构建在哺乳动物中表达的光调节基因元件．

英文摘要：

The filamentous fungus Neurospora crassa is an important model organism for studying genetic regulation, circadian rhythm and light response. This review summarized the structure and functions of WC-1 and VVD, and their participation in regulation of circadian rhythm and photoadaptation. All known light responses in Neurospora are regulated by blue light through two photoreceptors WC-1 and VVD. WC-1 is a transcription factor in this fungus and initiated the light response, generating a lot of light-responded proteins, such as VVD. VVD suppresses the transcription function of WC-lthrough negative feedback mechanism. In addition, the vvd gene has been applied to construct the photoresponsive elements of various genes in mammalian systems.