目的探讨脑血管储备能力(cerebrovascular reserve,cVR)与一侧颈内动脉狭窄程度的关系。方法选择脑梗死患者85例,其中颈内动脉狭窄组59例,对照组26例。分别通过吸入5%CO2和95%O2混合气体诱发高碳酸血症,计算大脑中动脉血流速度变化。结果颈内动脉狭窄组患者CVR较对照组明显降低[(22.47±12.45)%vs(37.25±11.77)%,P〈0.01]。cVR与颈内动脉狭窄程度呈负相关(CI=-0.6587,P〈0.01)。颈内动脉狭窄是CVR下降的独立危险因素(OR=5.149,95%CI:2.682~9.858,P〈0.01)。结论颈内动脉狭窄是影响CVR的独立危险因素,检测cVR可能预测颈内动脉狭窄程度。
Objective To study the relation between cerebrovascular reserve(CVR) and unilateral internal carotid artery(ICA) stenosis. Methods Eighty-five patients with cerebral infarction(ineluding 59 patients with ICA stenosis) served as an ICA stenosis group and 26 patients without ICA stenosis served as a control group in this study. Hypercapnia was induced by inhaling 5% CO2 and 95%O2 mixed gas. The blood flow rate in middle cerebral artery was measured. Results The CVR was significantly lower in ICA stenosis group than in control group (22.47%± 12.45% vs 37.25%±11.77% ,P〈0. 01). The CVR was positively correlated with the severity of ICA stenosis(CI=-0. 6587, P〈0.01), indicating that ICA stenosis is an independent factor for the reduced CVR(OR=5.149,95%CI:2. 682--9. 858,P〈0. 01). Conclusion ICA stenosis is an independent factor for CVR and detection of CVR can predict the severity of ICA stenosis.