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中文摘要：
本项目是在观察到HSP65经粘膜免疫能预防高胆固醇膳食家兔发生动脉粥样硬化的基础上，采用基于抗体铰链区的二聚化技术建立功能性表位肽段扫描技术，应用该技术对结核分支杆菌HSP65与动脉粥样硬化有关联的表位进行功能性扫描，以找出动脉粥样硬化的致病表位和保护性功能表位为研究重点,在保留HSP65抗动脉粥样硬化疗效的基础上，结合应用我们建立的"重复肽效应"疫苗研制技术应用选出的保护性表位初步探索研究疗效更好的动脉粥样硬化的新型疫苗。
结论摘要：
英文主题词HSP65;Antigen epitope;Function mapping;Atherosclerosis;Vaccine
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期刊论文
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