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中文摘要：
样品前处理装置独立于分析仪器，使样品前处理和分析检测变成两独立的过程，并以离线模式手工操作，严重影响了分析速度和分析结果的准确度、精密度。同时，各种样品前处理装置功能单一、普适性差。因此，发展样品前处理在线联用技术与装置是分析化学发展的必然趋势。针对复杂体系分析中存在的样品前处理瓶颈问题，结合课题组长期在样品前处理装置和介质研究中形成的基础和优势，本项目拟开展多功能集成化在线样品前处理联用系统的研制。设计研制在线预处理、在线富集、在线检测的通用接口装置；筛选和制备新型样品前处理介质，研制在线富集装置；通过模块化系统集成，构建多功能在线样品前处理联用系统；应用该系统研究生物、环境、食品和医药等复杂样品中痕量组分及其代谢物的在线分析方法。该项目研究将极大地推动分析化学的发展，促进生命科学、环境科学等交叉学科的研究，研究成果在食品安全、临床检验、环境保护、药物研发等领域有广泛的应用前景。
英文摘要：
sample preparation；microextraction unit；online separation and enrichment；coupling system；complex sample
结论摘要：
针对复杂体系分离分析中存在的样品前处理瓶颈问题，本项目开展了多功能在线样品前处理联用系统的研制及其应用研究。设计研制了在线采样、在线分离富集、在线检测接口装置；筛选和制备新型样品前处理介质，研制在线微萃取分离富集部件，构建在线样品前处理联用系统；研究了生物、环境、食品和医药等复杂样品中痕量组分的在线分析方法。 设计研制了14套在线采样、在线分离富集、在线检测接口装置，构建了3类14套在线样品前处理联用系统，包括4套场辅助在线样品前处理-色谱联用系统、6套固相（微）萃取在线样品前处理-色谱分析联用系统 4套在线样品前处理-光谱分析联用系统。筛选和研制了7类23种新型样品前处理介质，研制了25件分离富集微萃取部件。发展了系列生物、环境、食品和医药等复杂样品中痕量组分在线分析方法。 研究成果在Analytical Chemistry、Journal of Chromatography A等重要学术刊物上发表论文85篇，其中SCI收录论文75篇、ESI高被引论文1篇。完成发明专利6件，其中授权4件、公开2件。项目在研期间，有1名教师晋升为教授、3名晋升为副教授；培养了3名访问学者、10名博士生、15名硕士生、6名本科生；构建了一支多学科交叉的分析仪器研究队伍。举办国家级及省级学术会议各1次；团队成员参加积极学术交流。研究成果将推动分析化学的发展，促进生命科学、环境科学等学科的研究，在食品安全、临床检验、环境保护、药物研发等领域有广泛的应用前景。
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期刊论文
Hybrid field-assisted solid-liquid-solid dispersive extraction for the determination of organochlori
Preparation of phytosterols and phytol from edible marine algae by microwave-assisted extraction and
A consecutive preparation method based upon accelerated solvent extraction and high-speed counter-cu
Novel metal-ion-mediated, complex-imprinted solid-phase microextraction fiber for the selective reco
Preparation of sulfonated graphene/polypyrrole solid-phase microextraction coating by in situ electr
Rapid analysis of trace volatile formaldehyde in aquatic products by derivatization reaction-based s
Microwave-assisted extraction coupled with counter-current chromatography and preparative liquid chr
Determination of iodate in iodized salt and water samples by shell-isolated nanoparticle-enhanced Ra
Diazotization-coupling reaction-based selective determination of nitrite in complex samples using sh
Novel magnetic SPE method based on carbon nanotubes filled with cobalt ferrite for the analysis of o
Porous molecularly imprinted monolithic capillary column for on-line extraction coupled to high-perf
Microwave-assisted extraction coupled with countercurrent chromatography for the rapid preparation o
Fabrication of gold nanoparticle-embedded metal-organic framework for highly sensitive surface-enhan
Synthesis of nanoscale titania embedded in MIL-101 for the adsorption and degradation of volatile po
Online micro-solid-phase extraction based on boronate affinity monolithic column coupled with high-p
Novel metal-ion-mediated complex-imprinted solid-phase microextraction ？ber for the selective recogn
Novel metal ion-mediated complex imprinted membrane for selective recognition and direct determinati
A novel protocol for molecularly imprinted polymer filaments online coupled to GC-MS for the determi
Co-precipitation assisted cloud point extraction coupled with high performance liquid chromatography
Acrylamide-modified graphene for online micro-solid-phase extraction coupled to high-performance liq
In-situ loading ofwell-dispersed silver nanoparticles on nanocrystalline magnesium oxide forreal-tim
Aptamer recognition induced target-bridged strategy for proteins detection based on magnetic chitosa
Simpleand excellent selective chemiluminescence -based CS2 on-line detection system for rapidanalysi
In situ solvothermal growth of metal-organic framework-5 supported on porous copper foam for noninva
Rapid analysis of ractopamine in pig samples by dummy-template imprinted solid-phase extraction coup
Dynamic pH junction high-speed counter-current chromatography coupled with microwave-assisted extrac
Separation and purification of steroidal saponins from Paris polyphylla by microwave- assisted extra
Multilayer Interparticle Linking Hybrid MOF-199 for Noninvasive Enrichment and Analysis of Plant Hor
Porous boronate affinity monolith for on-line extraction coupled to high-performance liquid chromato
Molecularly imprintedpolymer as a novel solid-phase microextraction coating for selective enrichment
One-step sonoelectrochemical fabrication of gold nanoparticle/carbon nanosheet hybrids for efficient
Separationand analysis of trace volatile formaldehyde in aquatic products by a MoO3/ polypyrroleinte
Microwave accelerated selective Soxhlet extraction for the determination of organophosphorus and car
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