中文摘要：

观察 Xuebijing 注射的效果的目的() 在树枝状的房间(DC ) 和 T 上淋巴细胞，和它全身的豺狼座 erythematosus (SLE ) 上的治疗学的效果的潜在的机制。方法 A 广泛地使用了老鼠模型， 810 个星期的 SLE 容易的 BLLF1 老鼠，被采用。老鼠随机被划分成 4 个组：组们为 SLE 容易的 BLLF1 老鼠经由 intraperitoneal 管理与 6.4 mL/kg 的剂量与 Xuebijing 注射对待的一个正常的组，一个模型组和二个处理 8 个星期(处理 A 组) 和 10 个星期(处理 B 组) 变老。肾的织物节与 Massons 三色、周期的酸银的 methenamine 被染色。在肾的组织病理学说的变化被轻显微镜学评估。从怒气孤立响应 concanavalin A (反对 A ) 刺激 T 房间增长的 DC 的能力是坚定的。与模型组，相比结果在二个处理组的 anti-dsDNA 抗体的层次显著地减少了(P < 0.01， P < 0.05 ) ，并且浆液 creatinine 的层次和血脲氮增加了(P < 0.01， P < 0.05 ) 。病理学的变化在模型组在肾被发现。组织病理学说的畸形在二个处理组被减轻。有 Xuebijing 注射的处理另外显著地 upregulated 由与模型组相比的 DC 的 CD80， CD86 和主要 histocompatibility 班 II 的表示(P < 0.05 ) 。当从 BLLF1 老鼠的脾的 T 淋巴细胞与在为 3 和 5 天的 1:100， 1:150 和 1:200 的比率的 DC 是 co 有教养的时， T 淋巴细胞的增长与正常的组相比被压制(P < 0.05 ) ，但是这被 Xuebijing 注射在一样的条件下面恢复。在模型组，肿瘤坏死因素(TNF ) 铺平 - 显著地与正常的组相比在上层清液被提高(P < 0.01 ) ， interleukin-2 层次减少了(P < 0.05 ) ，当这些变化显著地在 Xuebijing 处理组被减轻时。结论 Xuebijing 注射在 SLE 容易的 BLLF-1 老鼠减轻了肾的损害。机制力量被 DC，和 Xuebijing 注射通过影响 T 房间极化调停可能是与 SLE 在病人压制有免疫力的机能障碍的潜在的药。

英文摘要：

Objective： To observe the effects of Xuebijing Injection （血必净注射液） on dendritic cells （DCs） and T lymphocytes, and the potential mechanisms of its therapeutic effect on systemic lupus erythematosus （SLE）. Methods： A widely used mouse model, SLE-prone BLLF1 mice aged 8-10 weeks, was employed. Mice were randomly divided into 4 groups： a normal group, a model group and two treatment groups treated with Xuebijing Injection with a dose of 6.4 mL/kg via intraperitoneal administration for SLE-prone BLLF1 mice aged 8 weeks （treatment A group） and 10 weeks （treatment B group）. Renal tissue sections were stained with Masson＇s trichrome and periodic acid-silver methenamine. Histopathological changes in the kidney were evaluated by a light microscopy. The capacity of the DCs isolated from the spleen to stimulate the T cell proliferation in response to concanavalin A （Con A） was determined. Results： Compared with the model group, levels of anti-dsDNA antibodies in the two treatment groups decreased remarkablely （P〈0.01, P〈0.05）, and levels of serum creatinine and blood urea nitrogen increased （P〈0.01, P〈0.05）. Pathological changes were found in the kidney in the model group. Histopathological abnormalities were alleviated in the two treatment groups. Treatment with Xuebijing injection also significantly upregulated the expression of CD80, CD86 and major histocompatibility class Ⅱ by DCs compared with the model group （P〈0.05）. When splenic T lymphocytes from BLLF1 mice were co-cultured with DCs at ratios of 1：100, 1：150 and 1：200 for 3 and 5 days, the proliferation of T lymphocytes was suppressed compared with the normal group （P〈0.05）, but this was restored by Xuebijing Injection under the same conditions. In the model group, levels of tumor necrosis factor （TNF）-α in supernatants were significantly elevated compared with the normal group （P〈0.01）, interleukin-2 levels decreased （P〈0.05）, while these changes were significantly al