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线粒体融合蛋白2的结构与功能研究进展
  • ISSN号：0559-7765
  • 期刊名称：《生理科学进展》
  • 时间：0
  • 分类：Q26[生物学—细胞生物学] Q253[生物学—细胞生物学]
  • 作者机构：[1]温州医科大学附属第一医院急诊中心,温州325000, [2]解放军总医院第一附属医院创伤研究中心,北京100048
  • 相关基金：国家重点基础研究发展规划项目（2012CB518102）; 国家自然科学基金（81130035,81372054,81121004,81571937）资助课题
作者： 应岚[1], 卢中秋[1], 姚咏明
关键词： 线粒体融合蛋白2, 线粒体, 内质网应激, 自噬, 线粒体自噬
中文摘要：

线粒体融合蛋白2（mitofusin 2,Mfn2）位于线粒体外膜上,是线粒体外膜融合的重要蛋白之一。研究发现,它不仅参与调控线粒体形态结构,还与细胞代谢、增殖、凋亡密切相关。近年来资料提示,Mfn2参与调控内质网应激、自噬、线粒体自噬等方面。由于Mfn2作用复杂,生理状态下细胞内必定存在精细的调控网络以使其保持在稳定水平。本文概括介绍了Mfn2结构、功能及其调控机制新进展。

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期刊信息
  • 《生理科学进展》
  • 北大核心期刊（2011版）
  • 主管单位:中国科协
  • 主办单位:中国生理学会　北京大学
  • 主编：王宪
  • 地址：北京海淀区学院路38号北京大学医学部
  • 邮编：100191
  • 邮箱：skj2@bjmu.edu.cn
  • 电话：010-82802443
  • 国际标准刊号：ISSN：0559-7765
  • 国内统一刊号：ISSN：11-2270/R
  • 邮发代号:2-567
  • 获奖情况:
  • 2000年中国科协择优支持高科技基础性期刊资助
  • 国内外数据库收录:
  • 美国化学文摘（网络版）,荷兰文摘与引文数据库,美国生物医学检索系统,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊（2004版）,中国北大核心期刊（2008版）,中国北大核心期刊（2011版）,中国北大核心期刊（2014版）,中国北大核心期刊（2000版）
  • 被引量:11995