欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
目的研究白藜芦醇对正常豚鼠心室肌细胞延迟整流钾电流的影响,旨在探讨白藜芦醇抗心律失常作用机制。方法酶解法分离豚鼠单个心室肌细胞,应用全细胞膜片钳技术研究白藜芦醇对豚鼠单个心室肌细胞钾电流的影响。结果白藜芦醇可明显增强慢性激活延迟整流钾电流（IKS）,并呈剂量依赖性。结论白藜芦醇可增强IKS,缩短动作电位时程（APD）。
英文摘要：
Objective To investigate the effects of resveratrol on the potassium current in guinea pig ventricular myocytes. Methods Enzyme digestion was performed to isolate single ventricular myocyte of guinea pig and whole-cell patch-clamp technique was used to record potassium current. Results In ventricular myocytes of guinea pig, the slow component of the cardiac delayed rectified potassium current （IKS） Was enhanced by resveratrol in a concentration dependent manner; whereas the rapid component of the cardiac delayed rectified potassium current （IKr） was not changed by resveratrol. Conclusion Its underlying mechanism is the shortening of AID through selective enhancement of IKS.
同期刊论文项目
同项目期刊论文
Modulation of HERG K+ channel expression by the naturally-occurring antiarrhythmics matrine and oxym
Large-conductance Ca2+-activated K+ currents blocked and impaired by homocysteine in human and rat m
The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting H
Cardioprotective Effects and Underlying Mechanisms of Oxymatrine Against Ischemic Myocardial Injurie
JAK/STAT and PI3K/AKT Pathways Form A Mutual Transactivation Loop and Afford Resistance to Oxidative
Indapamide induces apoptosis of GH3 pituitary cells independently of its inhibition of voltage-depen
Sphingolipid Metabolite Ceramide Causes Metabolic Perturbation Contributing to HERG K+ Channel Dysfu
Large-conductance Ca2+-activated K+ currents blocke and impaired by homocysteine in human and rat me
Volume-sensitive outwardly rectifying chloride channels are involved in oxidative stress-induced apo
Increasing Intracellular calcium of guinea pig ventricular myocytes induced by platelet activating f
位置：