中文摘要：

目的探讨超声造影时间-强度曲线各参数在甲状腺良恶性结节鉴别诊断中的价值。方法对99例甲状腺结节患者共118个结节进行超声造影检查，应用Qontrast软件进行脱机分析，分析超声造影时间-强度曲线各参数在良恶性结节及其周边正常组织间的差异性。结果分析结果显示恶性结节与周围正常组织间峰值强度（PEAK）、达峰时间（TTP）及局部血流量（RBF）差异有统计学意义（P〈0．05），各组间局部血容量（RBV）及造影剂平均渡越时间（MTT）差异均无统计学意义（P〉0．05）。结论超声造影结合时间一强度曲线可为鉴别甲状腺良恶性肿瘤提供更多有效的补充性信息，对临床鉴别诊断有一定参考价值。

英文摘要：

Objective To explore the value of each parameter from time-intensity curve in the thyroid nodules using con- trast-enhanced ultrasonography （CEUS）. Methods 118 thyroid nodules from 99 patients were examined using CEUS be- fore operation. The findings of CEUS of thyroid nodules were analyzed by Qontrast software. All of the thyroid nodules were divided into two categories according to pathology, thyroid malignant nodules （101 cases, including thyroid papillary carcinoma in 100 cases and medullary carcinoma of thyroid in 1 case） and thyroid benign nodules （17 cases, including nod- ular goiter in 16 cases and thyroid adenoma in 1 case）. PEAK （peak intensity）, TTP（Time-To-Peak）, RBV（regional blood volume）, RBF（regional blood flow） and MTT（mean transit time） of thyroid nodules and the adjacent thyroid paren- chyma were acquired automatically. The quantitative analysis findings of CEUS of each nodule（including benign and malig- nancy） and their adjacent thyroid parenchyma were compared adopting analysis of variance. Results There were signifi- cant differences in PEAK, TTP and RBF between thyroid malignant nodules and the adjacent thyroid parenchyma, where as there were no significant differences in PEAK, TTP and RBF between thyroid malignant nodules and thyroid benign nodules and between thyroid benign nodules and the adjacent thyroid parenchyma, In addition, the values of RBV and MTT were no significant difference among each groups （ P ~0.05）. Conclusion CEUS combined time-intensity curve can provide efficient and supplementary information to differentiate benign from malignant thyroid nodules.