中文摘要：

目的探讨超声造影在结节性甲状腺肿背景下良、恶性结节鉴别诊断中的应用价值。方法对结节性甲状腺肿疾病中的105个可疑结节均进行超声造影检查。分析其增强特点，所有病灶均经手术病理结果证实。结果恶性结节主要呈低增强（44．8％，30／67），良性结节主要呈等增强（39．5％，15／38），差异有统计学意义（P〈0．05）；良、恶性结节均以不均匀增强表现为主（60．5％、6817％），差异无统计学意义（P〉0．05）。恶性结节主要呈慢进同出（62.7％，42／67），良性结节主要呈同进同出（50％，19／38）。差异具有统计学意义（P〈0.01）。结论超声造影对鉴别结节性甲状腺肿背景下良、恶性结节有一定的诊断价值。

英文摘要：

Objective TO evaluate the application of contrast-enhanced ultrasonography （CEUS） in differential diagnosis between benign and malignant thyroid nodules in patients with nodular goiter. Methods One hundred and five suspected thy- roid nodules in patients with the nodular goiter were examined by CEUS. The enhanced characteristics of the nodules were ana- lyzed and the pathological diagnosis was obtained from surgically resected nodules. Results The dominant enhanced pattern was isoenhancement for benign thyroid nodules （39.5%, 15/38） and hypoenhancement for the malignant one （44.8%, 30/67） re- spectively. There was significant difference of the enhanced pattern between benign and malignant nodules（P〈0.05）. Most of the nodules appeared as heterogeneous enhancement both in benign（60.5%） or malignant （68.7%） ones. Most of the malignant nod- ules （62.7%, 42/67） presented ＂wash-in slowly＂ and ＂wash-out simultaneously＂ signs, whereas 50% of the benign nodules ap- peared as ＂wash-in simultaneously＂ and ＂wash-out simultaneously＂ signs（P〈0.01）. Conclusion CEUS is valuable in the diagno- sis of benign and malignant thyroid nodules in patients with nodular goiter.