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中文摘要：
目的研究宫颈癌组织中过氧化物酶体增殖物激活受体γ的表达及其意义。方法采用免疫组织化学SABC法,检测40例宫颈癌组织、10例宫颈炎组织和10例非典型增生宫颈组织切片中的PPARγ的表达,结合病理学分型、临床分期、放疗敏感性探讨其意义。结果 PPARγ在3组中均有一定程度的表达,但宫颈癌组织中PPARγ的表达明显高于宫颈炎组织及非典型增生宫颈组织,差异有统计学意义（P〈0.05）;PPARγ分别与宫颈癌临床分期、放疗敏感性和骨、肺、肝等远处转移和5年生存期有关,差异有统计学意义（P〈0.05）。结论宫颈癌组织中PPARγ的表达均显著增高,对判断宫颈癌预后及指导临床治疗有重要的参考意义。
英文摘要：
Objective To investigate the expression and clinical significance of PPARγ in cervical carcinoma.Methods Expressions of PPARγ in 40 cases of formalin-fixed,paraffin-embeded cervical carcinoma tissues,0 cases of cervicitis tissues and 10 cases of cervical intraepithelial neoplasia tissues,were examined using Strept-Avidin-Biotin Complex（SABC） immunohistochemical method.Results PPARγ was mainly localized in the nucleus and cytoplasm of the tumor cell.It was expressed in each group with different levels,but the expression rate of PPARγ in cervical carcinoma was significantly higher than those in cervicitis tissues and cervical intraepithelial neoplasia tissues（P 〈 0.05）.It was well associated with the clinic stages,radiosensitivity,5-year survival time and meta-stasis（lymph node,skeleton,liver,lung,etc） of the carcinoma（P 〈 0.05）.Conclusion High level expressions of PPARγ may serve as meaningful indicators for prognosis and clinical therapy of the cervical carcinoma.
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