中文摘要：

目的：分析新疆维吾尔族妇女子宫颈鳞癌死亡相关蛋白激酶（death-associated protein kinase,DAPK）基因启动子甲基化,确定DAPK基因启动子甲基化同新疆维吾尔族妇女子宫颈鳞癌发生的相关性。方法：运用甲基化特异性PCR（methylation-specific polymerase chain reaction,MSP）法检测维吾尔族妇女40例子宫颈鳞癌患者和40例子宫颈正常组织DAPK基因启动子甲基化。结果：维吾尔族妇女子宫颈鳞癌DAPK基因启动子甲基化率为65.0%（26/40）,正常子宫颈组织中DAPK基因启动子甲基化检出率为7.5%（3/40）。结论：DAPK基因启动子甲基化与维吾尔族妇女子宫颈鳞癌发生相关。

英文摘要：

Objective：Analysis of the promoter methylation of DAPK gene in cervical squamous cell carcinoma （SCC） of Uigur women,studying the promoter methylation of DAPK gene association with cervical squamous cell carcinoma of Uigur women in Xinjiang.Methods：The promoter methylation of DAPK gene in 40 patients with SCC and 40 normal cervical tissues by using methylation-specific polymerase chain reaction（MSP）.Results：The promoter methylation of DAPK gene in cervical squamous cell carcinoma samples of Uigur women were 65.0%（26 of 40）,whereas,the promoter methylation of DAPK gene in normal cervical tissues were 7.5%（3/40）.Conclusion：The promoter methylation of DAPK gene between cervical squamous cell carcinoma of Uigur women and normal cervical tissues of Uigur women were significant difference, the promoter methylation of DAPK gene were associated with squamous cell carcinoma of Uigur women tumorigenesis.