中文摘要：

目的：探讨CCNA1基因启动子区域甲基化与维吾尔族妇女子宫颈癌的相关性。方法：采用甲基化特异性PCR（MSP）方法,对40例子宫颈癌患者手术切除肿瘤组织及其40例正常子宫颈组织CCNA1基因启动子区域甲基化进行检测。结果：CCNA1基因在40例子宫颈癌中甲基化率为87.5%,正常子宫颈组织中甲基化率为2.5%,两者比较差异有统计学意义（P〈0.01）。结论：CCNA1基因启动子甲基化与维吾尔族妇女子宫颈癌发生相关。

英文摘要：

Objective： To explore the correlation between CCNA1 gene promoter region methylation and cervical cancer in Uyghur women. Methods： DNA methylation- specific PCR （MSP） method was used to detect CCNA1 gene promoter region methylation in tumor tissue samples obtained by surgery from 40 patients with cervical cancer and normal cervical tissue samples from 40 healthy cases. Results： The rate of CCNA1 gene promoter methylation in 40 patients with cervical cancer was 87. 5%, and the rate of CCNA1 gene promoter methyla- tion in normal cervical tissue samples was 2. 5%, there was statistically significant difference between the two groups （P 〈 0. 01 ） . Conclu- sion： CCNA1 gene promoter region methylation is correlated with the occurrence of cervical cancer in Uyghur women.