中文摘要：

为探讨新疆维吾尔族宫颈癌组织中C/EBPα第一外显子突变与HPV16感染的关系。收集46例新疆维吾尔族宫颈癌标本,采用基因测序方法检测C/EBPα第一外显子的突变,利用PCR扩增方法分析HPV16病毒的感染,进行统计学分析。结果发现C/EBPα第一外显子突变的患者HPV16病毒感染率高。且C/EBPα第一外显子突变的患者与未突变的患者的HPV16病毒的感染率存在显著性差异。McNemanr检验P〈0.05双侧。由此可知,新疆维吾尔族宫颈癌组织中C/EBPα基因第一外显子突变与HPV16病毒的感染相关。C/EBPα第一外显子突变可能是导致宫颈癌的一个重要因素。

英文摘要：

To explore the relationship between the first exon of C/EBPα gene mutation and HPV16 infection in cervical cancer tissues of Uigur women in Xinjiang.46 cervical cancer tissue samples of Uigur women were collected,the first exon of C/EBPαgene mutation detected by gene sequencing method and HPV16 virus infection analyzed by PCR amplification.It was discovered that HPV16 infection rate was higher in patients with the first exon of C/EBPα gene mutation than without mutation,and there was significant difference. Therefore,The first exon of C/EBPα mutation was related to HPV16 virus infection in cervical cancer tissues of Uigur women in Xinjiang,the first exon C/EBPα gene mutation play a possible role in cervical cancer genesis.