目的:研究C/EBPα蛋白在新疆维吾尔族妇女子宫颈鳞癌组织中的表达及临床意义。方法:采用免疫组化S-P法对36例子宫颈鳞癌组织、26例慢性子宫颈炎组织中C/EBPα蛋白的表达进行检测。结果:新疆维吾尔族妇女慢性子宫颈炎与子宫颈鳞癌组织中C/EBPα蛋白的表达具有显著性差异(P〈0.05);并且C/EBPα蛋白的表达与肿瘤的病理分级有关(P〈0.05)。结论:C/EBPα蛋白与新疆维吾尔族的子宫颈鳞癌有着密切的关系,该基因可能是一种潜在的抑制子宫颈鳞癌发生的基因。
Objective:To discuss the expression and clinical significance of C/EBPαin Xinjiang Uigur squamous carcinoma of the cervix. Methods:Immunohistochemistry S-P method was used to detect the expressions of C/EBPα in 62 patients with Uigur squamous carcinoma of the cervix(36) . Results:C/EBPαexpressed with a different degree in Xinjiang Uigur squamous carcinoma of the cervix and chronic cervicitis(P0.05);In addition,the expression of C/EBPαwere positive correlated with the hierarchical pathology of the Uigur squamous carcinoma of the cervix(P0.05) . Conclusion:C/EBPαhave a close relationship with Xinjiang Uigur squamous carcinoma of the cervix;This gene may be a larvaceous gene of squamous carcinoma of the cervix carcinogenesis.