对Alu剪接位点双碱基的类型、分布进行了分析,发现非标准剪接(不满足GT-AG规则)占很大优势。而且非标准剪接的分布频率会随不同的染色体而变化,在Alu剪接较多的11、12、17号染色体上分布最多。通过对Alu及其剪接住点碱基关联的计算分析,说明在Alu中剪接位点双碱基的这种异常使用主要是由Alu中二联体的关联压力造成的,从而表明这种重复序列对生命活动的多样化起着重要作用。
analysis on the types and distribution of splice sites in Alus indicates that non- standard sites are abundant as a departure from the GT- AG rule. The frequencies of non - standard splice sites vary with chromosomes, such as more residing on chr. 11, 12, 17. By a statistical approach, we found that the splice sites are subject to dinucleotide appearances in Aius, and thereby such repetitive elements have increased the versatility of the genome.