欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
生长抑制因子（inhibitor of growth，ING）家族成员是候选的抑癌基因．ING蛋白参与磷脂酰肌醇介导的脂类信号转导通路及激素介导的通路，能够与组蛋白乙酰转移酶、去乙酰化酶等结合参与染色质的重构，调节基因的转录，与p53协同作用，抑制细胞生长，诱导细胞凋亡和DNA损伤修复．ING家族成员通过对基因表达的表观遗传学调控将细胞周期、细胞凋亡和衰老等生物学过程有机联系起来．
英文摘要：
Inhibitor of growth （ING） family proteins belong to candidate tumor suppressor proteins. The ING proteins participate in PtdInsPs-mediated lipid signaling and hormone signaling pathways. They are associated with histone acetyltransferase, histone deacetylase and play a role in chromatin remodeling and gene transcription regulation. ING proteins regulate cell growth, apoptosis and DNA damage repair in p53 dependent manner; thus linking the processes of cell cycle regulation, apoptosis and cellular aging through epigenetic regulation of gene expression.
同期刊论文项目
同项目期刊论文
Two-dimensional blue native/SDS PAGE analysis reveals HSPs chaperone machinery involved in HBV produ
Proteome-wide prediction of signal flow direction in protein interaction networks based on interacti
JAB1 interacts with pro-apoptotic BH3-only BclGs and involved in the regulation of mitochondrial apo
Deactivation of IKK by CUE domain containing 2 (CUEDC2) via recruitment of the protein phosphatase P
First insight into human liver proteome from PROTEOMESKY-LIVERHu 1.0, a publicly-available database.
Proteomic screen defines the Hepatocyte Nuclear Factor 1binding partners and identifies HMGB1 as a n
Functional polymorphisms in the promoters of MMP-1, MMP-2, MMP-3, MMP-9, MMP-12 and MMP-13 are not a
Systematic characterization of the covalent interactions between (—)-epigallocatechin gallate and pe
A New Strategy to Filter out False Positive Identifications of Peptides in SEQUEST Database Search R
NuSAP is degraded by APC/C-Cdh1 and its overexpression results in mitotic arrest dependent of its mi
Phosphoproteome Profile of Human Liver Chang’s cell Based on 2-DE with Fluorescence Staining and MAL
Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavir
Proteome analysis of hepatocellular carcinoma by two-dimensional difference gel electrophoresis: nov
Functional Polymorphisms and Haplotype in the Promoter of MMP-2 Gene Are Associated with Risk of Nas
MDM2 Promoter SNP309 is Associated with Risk of Occurrence and Advanced Lymph Node Metastasis of Nas
Lack of Association between the Functional Polymorphisms in the Estrogen-metabolizing Genes and Risk
No association of MMP-7, MMP-8, and MMP-21 polymorphisms with the risk of hepatocellular carcinoma i
期刊信息
位置：