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蛋白质翻译后修饰及定位对p53活性的调节作用
  • ISSN号：1004-0374
  • 期刊名称：《生命科学》
  • 时间：0
  • 分类：Q51[生物学—生物化学]
  • 作者机构：[1]军事医学科学院放射与辐射医学研究所,北京蛋白质组研究中心,蛋白质组学国家重点实验室,北京102206
  • 相关基金：北京市科委计划项目（H030230280290）; 国家自然科学创新群体基金（30621063）; 国家高技术研究发展计划项目（863计划）（2006AA02A310）; 国家重点基础研究发展规划项目（973项目）（2006CB910802）
作者： 张莹[1], 王建[1]
关键词： P53, 翻译后修饰, 定位, p53, post-translational modification, localization
中文摘要：

抑癌蛋白p53具有转录激活作用,在细胞应激条件下激活一系列下游靶分子蛋白,发挥其调节细胞周期、细胞凋亡及DNA修复的功能。本文着重叙述了磷酸化、泛素化、乙酰化等不同的翻译后修饰及定位调控与p53活性调节之间的关系、特点和作用。

英文摘要：

　Tumor suppressor p53 is a transcriptional activator that regulates cell cycle, apoptosis and DNA repair when cell sense stress stimuli. In this review, we summarize our current knowledge of the relationship, character and function of post-translational modifications and localization of p53 activity.

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期刊信息
  • 《生命科学》
  • 北大核心期刊（2008版）
  • 主管单位:中国科学院
  • 主办单位:国家自然科学基金委员会生命科学部 中国科学院生命科学与生物技术局 中国科学院生命科学和医学学部 中国科学院上海生命科学研究院
  • 主编：王恩多
  • 地址：上海岳阳路319号31号楼B座403中国科学院上海文献情报中心
  • 邮编：200031
  • 邮箱：CBLS@SIBS.AC.CN
  • 电话：021-54922830
  • 国际标准刊号：ISSN：1004-0374
  • 国内统一刊号：ISSN：31-1600/Q
  • 邮发代号:4-628
  • 获奖情况:
  • 1996年获上海市优秀科技期刊评比一等奖
  • 国内外数据库收录:
  • 中国中国科技核心期刊,中国北大核心期刊（2008版）
  • 被引量:9112