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中文摘要：
多烯类抗生素制菌霉素（Nystatin）具有广谱抗真菌作用，对新型隐球菌、念珠菌属及曲霉属等大多数深部真菌感染等均有良好疗效．对于其抗真菌机理，有人认为是多烯类抗生素与真菌细胞膜上的麦角固醇相结合，导致细胞膜通透性改变，氨基酸及电解质等外流，引起真菌死亡．但制菌霉素也能与哺乳动物细胞膜上的胆固醇结合后引起同样的损伤，故其毒性较大．
英文摘要：
Nystatin is a polyene antifurgal drug to which many molds and yeasts are sersitive, including cryptococcus neoformans, candida, aspergillus, etc. To realize the mechanism of nystatin more particularly, the techniques of SPR and impedance were used to investigate the interaction between nystatin and two kinds of solid-supported phospholipid membranes. The results show that nystatin could interact with pure phospholipid membranes, whether they are monolayer or bilayer. In addition, impedance spectra show that ion channels may be formed when nystatin interacted with phospholipid membranes.
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