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AG490: An inhibitor of hepcidin expression in vivo
  • ISSN号：1007-9327
  • 期刊名称：World Journal of Gastroenterology
  • 时间：2011.12.12
  • 页码：5032-5034
  • 分类：Q576[生物学—生物化学] X503.225[环境科学与工程—环境工程]
  • 作者机构：[1]State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
  • 相关基金：Supported by Grants from the Chinese Academy of Sciences, KZCX2-EW-404; National Natural Science Foundation of China, No. 21077128, 20921063 and 21177151
  • 相关项目：多氯联苯(PCBs)暴露对乳腺癌肿瘤转移的影响及相关分子机制的研究
作者： Zhang, Shu-Ping|Wang, Zhe|Wang, Li-Xin|Liu, Si-Jin|
关键词： HEPCIDIN, 体内, 贫血, 铁代谢, 炎症, 化合物, 激素, 小鼠, AG490, Hepcidin, Anemia, Inflammation
中文摘要：

生产肝的荷尔蒙， hepcidin，看起来是在铁的关键播放器新陈代谢。hepcidin 的 overexpression 是发炎的贫血症的内在的原因。禁止 hepcidin 表示的混合物的鉴定能改善与发炎联系的贫血症。在当前的学习，我们第一次证明了 AG490 显著地在老鼠废除 hepcidin 表示。我们的工作代表一条新奇途径为发炎的贫血症和发生在另外的条件下面的贫血症的治疗压制 hepcidin 表示。

英文摘要：

A liver-produced hormone, hepcidin, appears to be the key player in iron metabolism. The overexpression of hepcidin is the underlying cause of anemia of inflammation. The identification of compounds inhibiting hepcidin expression could ameliorate anemia associated with inflammation. In the current study, we have demonstrated for the first time that AG490 signifi cantly abolishes hepcidin expression in mice. Our work represents a novel approach to suppress hepcidin expression for treatment of anemia of inflammation and anemias occurring under other conditions.

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纳米银的胚胎发育毒性机理研究
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多氯联苯(PCBs)暴露对乳腺癌肿瘤转移的影响及相关分子机制的研究
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期刊信息
  • 《世界胃肠病学杂志：英文版》
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  • 被引量:12408