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气相色谱-质谱法测定人体血液样品中合成麝香
  • ISSN号：0254-6108
  • 期刊名称：环境化学
  • 时间：0
  • 页码：530-535
  • 分类：O657.34[理学—分析化学;理学—化学]
  • 作者机构：[1]中国科学院生态环境研究中心,环境化学与生态毒理学国家重点实验室,北京100085
  • 相关基金：国家自然科学基金重点项目（No.20837003）; 国家自然科学基金创新群体（20921063）资助项目
  • 相关项目：环境中PPCPs的迁移转化、生态健康风险及控制原理
作者： 胡正君|史亚利|蔡亚岐|
关键词： 合成麝香, 人体全血, 气相色谱-串联质谱(GC-MS), synthetic musks, human blood, gas chromatography-mass spectrometry
中文摘要：

采用气相色谱-质谱联用技术（GC-MS）,建立了测定人全血样品中5种多环麝香和2种硝基麝香的分析方法.血液样品前处理采用正己烷液-液萃取,硅胶柱层析净化,洗脱液经N2浓缩后用GC-MS选择离子监测模式（SIM）进行检测.使用该前处理方法,替代物标样荧蒽-d10的回收率为85%—120%.以六氯苯（13C）为内标进行定量,7种合成麝香的线性范围为0.5—10μg.l-1,检出限在0.25—0.30μg.l-1（S/N=3）范围内.应用本方法,对实际全血样品进行3个不同浓度的加标回收实验,所得合成麝香的平均加标回收率均在77.9%—118.5%范围内,相对标准偏差在1.5%—9.5%之间.

英文摘要：

A novel method has been developed to determine five polycyclic musk fragrances and two nitro musk fragrances in human blood by GC-MS.Blood samples were extracted by n-hexane,cleaned up by silica gel column,and final eluate was concentrated with nitrogen before injection.Identification was carried out by GC-MS in the Selective Ion Monitor（SIM）mode.The recovery of fluenthene-d10,surrogate standard,was from 85.0% to 120.0%.The detection limits were from 0.25 to 0.30 μg·l-1（S/N=3）.Using hexachlorobenzene（HCB）13C6as the internal standard,good linear calibrations were obtained over the range of 0.5 to 10μg·l-1.Under the optimum conditions,the synthetic musk fragrances were recovered well at three different spiked concentrations with the recoveries ranging from 77.9% to 118.5%,and relative standard deviations ranging from 1.5% to 9.5%.

同期刊论文项目
持久性有毒化学污染物形态、环境过程与毒理效应
期刊论文 202 著作 2
环境中PPCPs的迁移转化、生态健康风险及控制原理
期刊论文 92
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期刊信息
  • 《环境化学》
  • 北大核心期刊（2011版）
  • 主管单位:中国科学院
  • 主办单位:中国科学院生态环境研究中心
  • 主编：郭良宏
  • 地址：北京2871信箱
  • 邮编：100085
  • 邮箱：hjhx@rcees.ac.cn
  • 电话：010-62923569
  • 国际标准刊号：ISSN：0254-6108
  • 国内统一刊号：ISSN：11-1844/X
  • 邮发代号:82-394
  • 获奖情况:
  • 国内外数据库收录:
  • 俄罗斯文摘杂志,美国化学文摘（网络版）,美国剑桥科学文摘,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊（2004版）,中国北大核心期刊（2008版）,中国北大核心期刊（2011版）,中国北大核心期刊（2014版）,英国英国皇家化学学会文摘,中国北大核心期刊（2000版）
  • 被引量:27127