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镉对小鼠骨生物力学及成骨细胞MG-63的影响
  • ISSN号：0254-6108
  • 期刊名称：《环境化学》
  • 时间：0
  • 分类：Q813.11[生物学—生物工程]
  • 作者机构：[1]北京林业大学,北京100083, [2]中国科学院生态环境研究中心,环境化学与生态毒理学国家重点实验室,北京100085, [3]山东省内分泌与代谢病研究所,济南250062
  • 相关基金：国家自然基金（21077128,20921063,21177151）资助.
作者： 黄泽昊[1,2], 侯艳丽[3], 李君平[3], 王立新, 张昌文, 王小岩, 荣海钦[3], 任建武[1], 曲广波
关键词： 镉, 骨质疏松, 成骨细胞, cadmium, osteoporosis, osteoblast.
中文摘要：

为了探讨镉对骨的影响及机制，选取7周龄C57BL／6J小鼠给予氯化镉2mg·kg-1腹腔注射，每周2次，染毒4周后进行了骨力学参数的测量．结果显示，暴露组股骨的最大弯曲应力及弹性模量降低，骨灰干重比下降．体外结果显示，氯化镉（CdCl2）的暴露影响人成骨肉瘤细胞MG．63的细胞形态、活力及增殖，并且呈剂量依赖性．因此，氯化镉暴露可导致小鼠骨量下降和骨力学性能下降，并对成骨细胞有明显的毒性．

英文摘要：

Cadmium is one of the most widely distributed heavy metals in the environment. In this study, C57BL/6 J mice were injected intraperitoneally with cadmium chloride at 2 mg .kg-1 twice per week. After 4week exposure, femur was taken out for 3-point-bending test and ashes-dry weight ratio evaluation. The maximal bending stress, elastic modulus and ashes-dry weight ratio of the femur were lower in the exposuregroup than that in the control one. Cadmium also affected the morphology, activity and proliferation of osteoblast-like ceils MG-63 in a dose-dependent manner. Our results suggest that cadmium exposure inducesthe decrease in bone mass and biomechanics in mice, and obvious toxicity to osteoblasts.

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期刊信息
  • 《环境化学》
  • 北大核心期刊（2011版）
  • 主管单位:中国科学院
  • 主办单位:中国科学院生态环境研究中心
  • 主编：郭良宏
  • 地址：北京2871信箱
  • 邮编：100085
  • 邮箱：hjhx@rcees.ac.cn
  • 电话：010-62923569
  • 国际标准刊号：ISSN：0254-6108
  • 国内统一刊号：ISSN：11-1844/X
  • 邮发代号:82-394
  • 获奖情况:
  • 国内外数据库收录:
  • 俄罗斯文摘杂志,美国化学文摘（网络版）,美国剑桥科学文摘,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊（2004版）,中国北大核心期刊（2008版）,中国北大核心期刊（2011版）,中国北大核心期刊（2014版）,英国英国皇家化学学会文摘,中国北大核心期刊（2000版）
  • 被引量:27127