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Susceptibility of male and female Japanese medaka （Oryzias latipes） to 2,4,6-trichlorophenol-induced micronuclei in peripheral erythrocytes
  • ISSN号：0023-074X
  • 期刊名称：《科学通报》
  • 时间：0
  • 分类：T[一般工业技术]
  • 作者机构：[1]State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
  • 相关基金：This work was supported by the Environmental Protection National Commonwealth Research Project （No. 200909040）;the National Natural Science Foundation of China （Grant No. 20921063）; and International Scientific and Technological Cooperation Projects by the Ministry of Science and Technology of China （No. 2009DFA91920）.
作者： Nannan LIU Mei MA Yiping XU Jinmiao ZHA Kaifeng RAO Zijian WANG[1]
关键词： 2, 4, 6-TRICHLOROPHENOL, GENOTOXICITY, Japanese, MEDAKA, piscine, MICRONUCLEUS, test, in, PERIPHERAL, erythrocytes, gender, difference
中文摘要：

2,4,6-trichlorophenol （2,4,6-TCP） is a wide- spread probable human carcinogen and has been proven to have genotoxicity in in vitro assays. However, little genotoxicity information and no micronuclei induction data for 2,4,6-TCP is available from in vivo tests, especially for sex-specific differences. Following a preliminary test, a piscine peripheral erythrocyte micro- nucleus assay was conducted on medaka （Oryzias latipes） after a 28-day exposure to 2,4,6-TCE In the present study, the mean micronuclei （MNC） frequencies of all of the groups increased in a dose-dependent manner, which indicated the potential genotoxicity of 2,4,6-TCE More- over, males were found to be more susceptible compared with females after a 28-day exposure to 2,4,6-TCP in all of the dosed groups above 10 ~tg-L-1. This is the first report on the potential of micronuclei induction and a sex-susceptible effect in the peripheral erythrocytes of mature fish after 2,4,6-TCP in vivo exposure.

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期刊信息
  • 《科学通报》
  • 北大核心期刊（2011版）
  • 主管单位:中国科学院
  • 主办单位:中国科学院
  • 主编：周光召
  • 地址：北京东黄城根北街16号
  • 邮编：100717
  • 邮箱：csb@scichina.org
  • 电话：010-64036120 64012686
  • 国际标准刊号：ISSN：0023-074X
  • 国内统一刊号：ISSN：11-1784/N
  • 邮发代号:80-213
  • 获奖情况:
  • 首届国家期刊奖,中国期刊方阵“双高”期刊,第三届中国出版政府奖
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  • 美国化学文摘（网络版）,美国数学评论（网络版）,美国工程索引,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊（2004版）,中国北大核心期刊（2008版）,中国北大核心期刊（2011版）,中国北大核心期刊（2014版）,中国北大核心期刊（2000版）
  • 被引量:81792