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中文摘要：
蛋白质生物合成过程的终止是由于第一类肽链释放因子识别终止密码子,并导致肽酰-tRNA酯键水解,释放出新合成的多肽链.近期,通过冷冻电镜、结晶学、核磁共振、分子动力学和生物化学等方面的研究,使第一类肽链释放因子的结构与功能逐渐清晰.对近期的研究进行了分析和整理.
英文摘要：
The process of protein synthesis is terminated by one of the three stop codons which are recognized by class Ⅰ polypeptide release factors. Subsequently, it could promote the hydrolysis of the ester bond of peptidy-tRNA, resulting in release of the nascent polypeptide. Recent results from cryoelectron microscopy, crystallography, NMR, molecular dynamic and biochemical experiments have shed considerable light on the function and structure of the class Ⅰ release factors. The progress in these aspects were summarized.
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