欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
出芽式血管生成是肿瘤血管生成主要方式，其中出芽过程受到多种信号通路和相关分子的调控。新的研究发现，血管内皮细胞除了受VEGF／VEGFR-2诱导转化为尖端细胞出芽外，VEGFR-3也会高表达于肿瘤血管内皮，对尖端细胞的选择以及肿瘤血管分支进行双向调控。该文重点阐述了VEGF／VEGFR与Dll4／Notchl信号通路的平衡对肿瘤血管出芽的重要意义，同时Ang／Tie、HIF、整合素等信号与VEGF／VEGFRs信号相互作用也对肿瘤血管出芽进行调控。靶向针对于出芽式肿瘤血管初始出芽阶段的抗血管治疗策略是抑制肿瘤血管生成的新的着眼点。
英文摘要：
Sprouting angiogenesis is the primary way of tumor an- giogenesis. The diverse pathways and molecules have been in- volved in angiogenesis, the tormation of new blood vessels. VEGF-A/VEGFR-2 has recently emerged as a key signal axis of angiogenesis. Moreover, VEGFR-3 which is highly expressed in the tumor vascular endothelial, plays a bimodal role in regulating angiogenesis by effectively controlling the number of vessel bran- ches and endothelial sprouts. The balance of VEGF/VEGFR andDll4/Notehl signaling pathways is significant in the sprouting an- giogenesis. The process of sprouting has been regulated by the in- tersection of VEGF/VEGFR signaling with other pathways, in- cluding angiopoieti/Tie, hypoxia-inducible factor, and integrin pathways. Thus, focuse on the initial stage of sprouting will be effective strategies for tumor anti-angiogenesis.
同期刊论文项目
同项目期刊论文
Bioactive tanshinones in Salvia miltiorrhiza inhibit the growth of prostate cancer cells in vitro an
Cryptotanshinone has diverse effects on cell cycle events in melanoma cell lines with different meta
Xanthatin induces cell cycle arrest at G2/M checkpoint and apoptosis via disrupting NF-κB pathway in
Comparative Effects of Hirudo, Frankincense, and Motherwort on Inhibition of Blood Platelet Aggregat
Luteolin reduces the invasive potential of malignant melanoma cells by targeting β3 integrin and the
Inhibition of hypoxia-induced epithelial mesenchymal transition by luteolin in non-small cell lung c
Effect of Aqueous Extracts of Several Kinds of Herbs on Human Platelet Aggregation and Expression of
Chemomodulatory effi cacy of lycopene on antioxidant enzymes and carcinogen-induced cutaneum carcino
Holothurian glycosaminoglycan inhibits metastasis and thrombosis via targeting of nuclear factor-kap
Inhibition of vascular endothelial growth factor-mediated angiogenesis involved in reproductive toxi
Holothurian Glycosaminoglycan Inhibits Metastasis and Thrombosis viaTargeting of Nuclear Factor-κB/T
Concerted Suppressionof STAT3 and GSK3β Is Involved in Growth Inhibition of Non-Small Cell LungCance
CryptotanshinoneActivates p38/JNK and Inhibits Erk1/2 Leading to Caspase-Independent Cell Deathin Tu
Luteolin reduces theinvasive potential of malignant melanoma cells by targeting β3 integrin and thee
Inhibition of hypoxia-induced epithelialmesenchymal transition by luteolin in non-small cell lung ca
The Angiogenic Responses Induced by Release of AngiogenicProteins from Tumor Cell-Activated Platelet
Cryptotanshinone, a novel tumor angiogenesisinhibitor, destabilizes tumor necrosis factor-a mRNA via
Chemopreventive efficacy of menthol on carcinogen-induced cutaneous carcinoma in mice throughinhibit
Cancer-promotingeffect of capsaicin on DMBA/TPA-induced skin tumorigenesis by modulatinginflammation
Holothurian glycosaminoglycan inhibits metastasis via inhibition of P-selectin in B16F10 melanoma ce
PKM2 Regulates Hepatocellular Carcinoma Cell Epithelial-mesenchymal Transition and Migration upon EG
PKM2 Regulates Hepatocellular Carcinoma Cell Epithelialmesenchymal Transition and Migration upon EGF
Phenolcarboxylic acids from medicinal herbs exert anticancer effects through disruption of COX-2 act
期刊信息
位置：