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中文摘要：
黑色素瘤是一种发生于黑色素细胞的恶性肿瘤，临床研究发现在晚期黑色素瘤患者中发生了BRAF（V600E）的突变。目前，临床上已批准的用于治疗BRAF突变黑色素瘤的靶向药物（如ipilimumab和vemurafenib）对黑色素瘤患者有很高的效率，与化疗相比能够明显延长无进展生存期和总生存期，但这些药物在体内所产生的效应是短暂的，大多数患者在不到1年内就会产生耐药。基于BRAF突变黑色素瘤耐药的现状，近几年对于其耐药机制的研究逐渐增多，该文对目前BRAF突变黑色素瘤耐药机制的研究进展及临床治疗策略进行综述，为临床的后续研究和治疗提供参考。
英文摘要：
Melanoma is a malignant tumor originated from mela- nin ceils. Clinical researches indicate that BRAF （V600E） has been detected in about 50% of patients with advanced melano- ma. Currently, drugs （such as ipilimumab and vemurafenib ） that have been approved in clinical usage for treating BRAF-mu- tated melanoma show high responses and prolong the progress- free survival and overall survival significantly, as compared with chemotherapy. However, responses are often short-lived, andmost patients develop drug resistance within one year. Recently, an increasing number of studies on drug resistance have been conducted. This paper reviews the research progress of mecha- nisms for BRAF-mutated melanoma, it also includes discussion about the clinical therapy strategies, which may provide refer- ences for follow-up research and clinical treatment.
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