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Epigenetic changes in colorectal cancer
  • ISSN号：1000-467X
  • 期刊名称：《癌症：英文版》
  • 时间：0
  • 分类：Q939.139[生物学—微生物学] S513.024[农业科学—作物学]
  • 作者机构：[1]Department of Gastroenterology & Hepatology, Chinese PLA General Hospital, Beijing 100853, P. R. China, [2]Medical College of Nankai University, Tianjin 300071, P. R. China
  • 相关基金：supported by grants from the National Basic Research Program(973Program No.2012CB934002,2010CB912802);National Key Scientific instrument Special Programme of China(Grant No.2011YQ03013405);National Science Foundation of China(Grant No.81121004,81071953)
作者： Yan Jia[1,2], Mingzhou Guo[1]
关键词： 遗传变化, 大肠癌, 表观, MICRORNA, 甲基化剂, 组蛋白修饰, 基因启动子区, 非编码RNA, DNA methylation, histone modification, microRNA （miRNA）, epigenetics, colorectal cancer （CRC）, field defect
中文摘要：

Epigenetic changes frequently occur in human colorectal cancer.Genomic global hypomethylation,gene promoter region hypermethylation,histone modifications,and alteration of miRNA patterns are major epigenetic changes in colorectal cancer.Loss of imprinting(LOI) is associated with colorectal neoplasia.Folate deficiency may cause colorectal carcinogenesis by inducing gene-specific hypermethylation and genomic global hypomethylation.HDAC inhibitors and demethylating agents have been approved by the FDA for myelodysplastic syndrome and leukemia treatment.Non-coding RNA is regarded as another kind of epigenetic marker in colorectal cancer.This review is mainly focused on DNA methylation,histone modification,and microRNA changes in colorectal cancer.

英文摘要：

Epigenetic changes frequently occur in human colorectal cancer. Genomic global hypomethylation, gene promoter region hypermethylation, histone modifications, and alteration of miRNA patterns are major epigenetic changes in colorectal cancer. Loss of imprinting （LOI） is associated with colorectal neoplasia. Folate deficiency may cause colorectal carcinogenesis by inducing gene-specific hypermethylation and genomic global hypomethylation. HDAC inhibitors and demethylating agents have been approved by the FDA for myelodysplastic syndrome and leukemia treatment. Non-coding RNA is regarded as another kind of epigenetic marker in colorectal cancer. This review is mainly focused on DNA methylation, histone modification, and microRNA changes in colorectal cancer.

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期刊信息
  • 《癌症：英文版》
  • 北大核心期刊（2008版）
  • 主管单位:教育部
  • 主办单位:中山大学肿瘤防治中心
  • 主编：曾益新
  • 地址：中国广州市东风东路651号
  • 邮编：510060
  • 邮箱：cjc@cjcsysu.cn
  • 电话：020-87345651
  • 国际标准刊号：ISSN：1000-467X
  • 国内统一刊号：ISSN：44-1195/R
  • 邮发代号:46-21
  • 获奖情况:
  • 广东省优秀期刊鼓励奖，1991年,2009、2010、2011年百杰期刊,2011-2014年RCCSE中国权威期刊,2012年中国国际影响力优秀学术期刊
  • 国内外数据库收录:
  • 美国化学文摘（网络版）,荷兰文摘与引文数据库,荷兰医学文摘,美国生物医学检索系统,美国剑桥科学文摘,美国科学引文索引（扩展库）,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊（2004版）,中国北大核心期刊（2008版）,瑞典开放获取期刊指南,中国北大核心期刊（2000版）
  • 被引量:30766