中文摘要：

目的评估0．1％溴芬酸钠水合物滴眼液与0．1％双氯芬酸钠滴眼液在飞秒辅助下准分子激光原位角膜磨镶术（FS—LASIK）后早期镇痛效果。方法临床病例对照研究。对2013年10月至2014年8月在北京同仁医院屈光中心选取双眼行FS—LASIK术的患者195例，根据患者就诊顺序按照奇偶数法随机分为3组：所有患者术前3d开始均常规局部使用0．5％左氧氟沙星滴眼液（4次／d）；0．1％溴芬酸钠水合物滴眼液组64例128只眼，术前3d开始加用0．1％溴芬酸钠水合物滴眼液（2次／d）；0．1％双氯芬酸钠滴眼液组61例122只眼，术前3d开始加用0．1％双氯芬酸钠滴眼液（40Vd）；对照组70例140只眼，术前3d不使用非甾体抗炎药。所有患者术后1d复查，调查患者的主观感觉（包括疼痛感、烧灼感、异物感、干涩感、视疲劳）。患者主观感觉根据程度分为0、1、2、3分，分别表示无、轻度、中度、重度。结果在LASIK术后早期患者疼痛和干涩感评分3组之间总体差异均有统计学意义（右眼F=5．11，84．29；左眼F=4．64，83．29；P〈0．05）；0．1％溴芬酸钠水合物滴眼液组与0．1％双氯芬酸钠滴眼液组之间差异均无统计学意义（右眼q=1．1317，0．1201；左眼q=1．2312，0．8479；P〉0．05）；0．1％溴芬酸钠水合物滴眼液组与对照组之间差异均有统计学意义（右眼q=4．3490，15．9102；左眼q=4．1853，16．1668；P〈0．05）；0．1％双氯芬酸钠滴眼液组与对照组之间差异均有统计学意义（右眼q=3．1381，15．5869；左眼q=2．8748，15．0968；P〈0．05）。在烧灼感、异物感、视疲劳评分3组之间总体差异均元统计学差异（右眼F=1．66，0．61，1．43；左眼F=2．29，0．82，1．07；P〉0．05）。每组双眼之间的差异均无统计学意义（P〉0．05）。结论0．1％溴芬酸钠水合物滴眼液与0．1％双氯芬酸钠滴眼液对FS—LASIK术?

英文摘要：

Objective To assess early postoperative analgesia of 0.1% bromfenac sodium hydrate ophthalmic solution and Diclofenac sodium ophthalmic solution after excimer laser in situ keratomileusis. Methods A case-control study. Form October 2013 to August 2014, 195 cases were collected and performed Femtosecond laser assisted LASIK in Beijing Tongren Hospital Refractive Center. Cases were randomly grouped according to the order in which the number of patient visits using Parity Act： All patients routinely used 0.5% levofloxacin ophthalmic solution （4 times per day）. 0.1%bromfenac sodium hydrate drops 64 cases （128eyes）, From preoperative 3d starting they were pointed with 0.1% bromfenac sodium hydrate drops （2 timesper day）; 0.1% Diclofenac sodium ophthalmic solution 61 cases （122 eyes）, From preoperative 3d starting they were pointed with 0.1% Diclofenac sodium ophthalmic solution （4 times per day）; the control group 70 cases （140 eyes）, without use of non-steroidal anti-inflammatory drug. On next day after surgery, the patient＇s subjective feeling （Pain, burning, foreign body sensation, dryness, eye fatigue） were investigated. According to the degree of patients＇ subjective feeling 0, 1, 2, 3 points represented none, mild, moderate, and severe, respectively. Results Scores about pain and dryness were statistically significant differences among the three groups （right eye F =5.11,84.29; left eye F =4.64, 83.29; P 〈0.05）, Differences was not statistically significant between 0.1% bromfenac sodium hydrate group and 0.1% diclofenac sodium groups （right eye q =1.1317, 0.1201; left eye q =1.2312,0.8479; P 〉0.05）; The difference were statistically significant between 0.1% bromfenac sodium hydrate drops and control groups （right eye q =4.3490, 15.9102; left eye q =4.1853, 16.1668; P 〈0.05）; The difference were statistically significant between 0.1% diclofenac sodium ophthalmic solution groups and control groups （right q =3.1381, 15.5869; eye q =2.8748, 15.0968; P 〈0.05）.