中文摘要：

随着飞秒激光技术的快速发展，多元化的角膜屈光手术给屈光不正患者带来了满意的临床效果。同时，飞秒激光角膜屈光术的安全性、有效性、稳定性及可预测性均得到了进一步的提高。然而，伴有角膜营养不良的屈光不正患者，尤其是Avellino角膜营养不良的年轻患者，在行飞秒激光角膜屈光术后，其病情将进一步加重，从而对视功能造成影响。本文中笔者对国内外报道的伴有Avellino角膜营养不良的屈光不正患者在行角膜屈光手术后，出现的角膜混浊程度加重、视力下降等情况进行分析，归纳已经报道的Avellino角膜营养不良的临床表现和基因筛查位点。研究结果表明，Avellino角膜营养不良应列为飞秒激光角膜屈光术的绝对禁忌证，故建议临床医师应在行飞秒激光角膜屈光术前加强对Avellino角膜营养不良的临床检查和基因筛查。

英文摘要：

With the rapid development of femtosecond laser technology, diversified corneal refractive surgeries bring satisfactory clinical effect for patients with ametropia. At the same time, the safety, effectiveness, stability and predictability of femtosecond laser corneal refractive surgery have been further improved. However, for ametropia patients with corneal dystrophy, especially for those young patients with Avellino corneal dystrophy, who have accepted femtosecond laser refractive surgery, their conditions will be further aggravated, thus affecting the visual function of them. In this paper, aggravation of maculae corneae and decreased vision of ametropia patients with Avellino corneal dystrophy after femtosecond laser refractive surgery were covered, as well as the clinical manifestations and gene screening sites of Avellino corneal dystrophy. Avellino corneal dystrophy is an absolute contraindication of femtosecond laser corneal refractive surgery. Therefore, Clinicians should strengthen the clinical examination and gene screening of Avellino corneal dystrophy before femtosccond laser corneal refractive surgery.