欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
亚甲基四氢叶酸还原酶（methylenetetrahydrofolate reductase，MTHFR）在叶酸和同型半胱氨酸代谢、DNA甲基化和DNA合成等方面起重要作用。MTHFR基因突变造成酶活性和耐热性降低，导致高半胱氨酸血症和DNA结构异常，从而影响多种疾病的发生。现已发现MTHFR基因多态性与心脑血管疾病、出生缺陷和一些肿瘤等多种疾病存在相关性。
英文摘要：
Methylenetetrahydrofolate reductase （MTHFR）, a pivotal enzyme in folate and homocysteine metabolism, regulates the proportional distribution of one-carbon moieties between cellular methylation reaction and nucleic acid synthesis. Different MTHFR mutations lead to moderate hyperhomocysteinaemia and DNA damage, which is a common risk factor for many diseases. It has been reported that two common MTHFR polymorphisms, C677T and A1298C, may be associated with cardiovascular disease, cerebrovascular disease , birth defect, cancer and other diseses.
同期刊论文项目
同项目期刊论文
期刊信息
位置：