中文摘要：

目的 测定白介素4（IL-4），白介素-17（IL-17）及γ-干扰素（IFN-γ）在急、慢性荨麻疹患者血中水平，探讨其在疾病中的作用。方法 对30例急性荨麻疹患者和30例慢性荨麻疹患者，用ELISA法测定血清IL4，IL-17及IFN-γ，并与正常对照组进行比较。结果ELISA检测血清IL-17在荨麻疹组有明显增高，尤其在慢性荨麻疹中，与对照组差异有统计学意义（P〈0．05）；IL-4在急性，慢性荨麻疹中有明显增高，与对照组差异有统计学意义（P〈0．05）；急慢性荨麻疹患者IFN-γ与对照组差异无统计学意义（P〉0．05）。结论 IL-4，IL-17分别在急性，慢性荨麻疹的发病中发挥了重要作用。

英文摘要：

Objective To investigate the levels of IL-4, IL-17 and IFN-γ in serum of the patients with acute and chron- ic urticaria,and to explore their roles in the disease. Methods The serum concentrations of IL-4, IL-17 and IFN-γ were detected by ELISA in 30 patients with acute urticarial ,30 patients with chronic urticaria, and normal controls. Results Compared with normal controls,the levels of IL-17 and IL-4 in the patients with urticaria, in particular, chronic urticaria, were significantly higher （ P 〈 0.05 ）. There was no significant difference in the level of IFN-γ between urticaria group and controls （P 〉 0.05 ）. Conclusion IL-17 and IL-4 play an important role in the pathogenesis of both acute and chronic urticaria.