中文摘要：

目的 探讨长期吸入糖皮质激素（GCS）治疗支气管哮喘、慢性阻塞性肺疾病对中老年人群骨代谢的影响.方法 将60例患者均分为观察组与对照组,对照组常规治疗,观察组长期吸入GCS,分别测定两组的骨密度、血骨钙素（BGP）及血骨碱性磷酸酶活力（BALP）水平.结果 两组均无骨质疏松和低骨量发生,观察组BGP及BALP与对照组及治疗前比较,差异无统计学意义（P＞0.05）.观察组与对照组5处平均绝对骨密度和相对骨密度差异无统计学意义（P＞0.05）.结论 长期吸入GCS对骨密度及骨代谢的影响不明显.

英文摘要：

Objective To understand the influence of long-term inhalation of glucocortieosteroid （GCS） on bone metabolism of the elderly in Foshan area in treatment of asthma and chronic obstructive pulmonary disease.Methods 60 patients were evenly divided into observation group and control group,each had 30 cases,the observation group were inhaled GCS for a long term.The bone mineral density,serum osteocalcin （BGP） and serum bone alkaline phosphatase ？ activity （BALP） level was determined in both groups.Results There was no osteoporosis and low bone mass＇ occured,~ BGP and BALP in two groups had no significant difference （P〉0.05）.The 5 mean absolute and relative bone mineral density in observation group and control group showed no significant difference （P〉0.05）.Conclusion Long-term inhalation of GCS doesn＇t show remarkable influence on bone mineral density or bone metabolism.