中文摘要：

目的利用静息态功能磁共振（fMPd）分析网络游戏成瘾者与伏核存在功能连接的脑区，了解伏核功能异常在网络游戏成瘾发病机制中的作用。方法网络游戏成瘾者和健康对照组各17例，扫描前上网玩耍自己喜欢的网络游戏，60min后突然中止网络使用，对被试的网络游戏渴求程度进行心理学测评；休息30min后进行静息态fMRI扫描，分别选取左、右侧伏核为感兴趣区进行脑功能连接分析，确定与双侧伏核有功能连接的脑区，并将激活程度与网络游戏渴求程度进行相关分析。结果网络游戏成瘾青少年对网络游戏内容的渴望程度、喜欢程度、再次上网的渴望程度明显高于健康对照组（P〈0．05）；网络游戏成瘾组的伏核与前扣带回、中脑、海马功能连接明显高于健康对照组，而与前额叶、颞叶及枕叶功能连接明显低于健康对照组（P〈0．05）；网络游戏成瘾者伏核与前额叶、前扣带回、中脑及海马的功能连接程度和网络游戏渴求程度存在相关性（r=0．70、0．76、0．65、0．79，P〈0．05）。结论网络游戏成瘾者伏核功能异常，提示伏核是网络游戏成瘾“奖赏系统”的重要组成部分，伏核功能异常可能参与了网络游戏成瘾的产生与维持。

英文摘要：

Objective To analyze the brain areas having functional connectivity with nucleus accumbens in internet game addicts with resting- state functional magnetic resonance imaging （fMRI）, and to find out the role of nucleus accumbens dysfunction in the pathogenesis of internet game addiction. Methods Seventeen participants with internet game addiction（IGA）, and seventeen healthy controls took part in this study. First, all subjects took 60 minutes for playing their favorite online games and then stopped immediately to assess degree of wishing to play of online games based on psychological measurement; MR imaging was performed on a Philips Intera 3.0T MR imaging scanner, after that, the left and right nucleus accumbens were selected as regions of interest （ROIs） separately, and the linear correlation between the nucleus accumbens and the entire brain was calculated to find out the functional connectivity of the nucleus accumbens during the resting state; Finally, a two - sample t test was performed to explore the functional connectivity difference between the internet game addicts and controls. Correlation analysis was performed to assess the relationship between the voxels value of the brain regions and degree of wishing to play online games within the IGA gourp. Results Compared with the controls, the score of the degree of wishing to play online games were higher in the internet game addicts （ P 〈 0. 05 ）. During the resting state, the functional connectivity between the nucleus accumbens and the anterior cingulate cortex, the midbrain, the hippocampal gyrus in the internet game addiction group were increased, the functional connectivity between the nucleus accumbens and the prefrontal cortex, the temporal lobe, the occipital lobe were decreased （P 〈 0.05）. The voxels value of the prefrontal cortex, the anterior cingulate cortex, the midbrain and the hippocampal gyrus in the game addiction group showed a positive correlation with the degree of wishing to play online games （ r = 0.70, 0. 76,