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中文摘要：
由于腺相关病毒具有独特的载体优势,越来越多地被应用在基因治疗中。大量文献表明,腺相关病毒可以携带目的 基因通过不同手术途径成功导入遗传性耳聋动物模型,在毛细胞,血管纹,支持细胞,螺旋神经节细胞等成功表达,实现形态学和功能学的恢复。本文总结应用腺相关病毒进行耳聋基因治疗的研究进展,突出其优势,总结成功经验及存在问题,为未来腺相关病毒在耳聋中的应用提供新思路。
英文摘要：
Adeno-associated virus has been used in gene therapies due to its unique gene vector advantages. Large amount of literature has demonstrated successful use of adeno-associated virus carrying various target genes in animal mod- els of hereditary hearing loss with different approaches, to be expressed in hair cells, stria vascularis, support cells, spiral ganglion cells, etc, for the purpose of restoration of morphology and fimction. This paper summarizes the application of adc- no-associated virus gene vectors in hereditary hearing loss, its advantages, successful experiences and problems in the past, and shares new ideas in its utilities in the future.
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