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中文摘要：
肌动蛋白结合蛋白是指能与肌动蛋白的单体、多聚体等结合的蛋白,肌动蛋白结合蛋白2（Transgelin-2）作为一种重要的肌动蛋白结合蛋白,可广泛分布在平滑肌细胞及非平滑肌细胞。Transgelin-2基因可广泛表达在全身各组织器官,其在亚细胞层面上有多种定位,且在不同病理生理状态下可能存在定位转移。Transgelin-2蛋白被认为参与了多种恶性肿瘤疾病,可能是特异性肿瘤标志物。本文对Transgelin-2蛋白的特性、亚细胞定位和相应生物学功能进行了综述,以期为相关机制研究提供可能的判断依据。
英文摘要：
Actin-binding protein is a protein that can combine with the actin monomer, polymer and other proteins. As an important actin-binding protein, actin-binding protein 2 （Transgelin-2） can distribute in the smooth muscle cells and non-smooth muscle cells. Transgelin-2 gene is widely expressed in various tissues and organs of the body, which is positioned on a variety of sub-cellular level, and it may be shifted position at different pathophysiological states. Transgelin-2 protein may be a specific tumor marker and is believed to participate in a variety of malignant diseases. In order to provide a possible reference for the relevant mechanism research, the characteristics of Transgelin-2 protein, subcellular localization and the corresponding biological functions were reviewed in this paper.
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