采用柱色谱等分离方法,对紫金龙Aconitum vilmorinianum var.altifidum W.T.Wang低极性部位的生物碱类化学成分进行分离纯化,依据其理化性质及波谱数据分析进行结构鉴定。从中分离、鉴定了7个二萜生物碱类化合物和1个二萜生物碱类复合物,分别为:黄草乌碱丁(1)、hemsleyaconitine G(2)、hemsleyaconitine F(3)、hemsleyaconitine A(4)、14-O-veratroylneoline(5)、塔拉胺(6)、lipoyunaconitine(7)和hemsleyadine(8)。化合物1~8均为首次从该植物中分离得到。
Seven diterpenoid alkaloids and one diterpenoid mixtures were isolated from the low-polar fraction of Aconitum vdmorinianum var. altifidum W. T. Wang by repeated column chromatography. Their structures were elucidated on the basis of their physic-chemical properties and by NMR spectral analysis. The alkaloids were identified as vilmorrianine D (1), hemsleyaconitine G (2), hemsleyaconitine F (3), hemsleyaconitine A (4), 14-O-veratroylneoline ( $ ), talati- samine (6) ,lipoyunaconitine (7) and hemshyadine (8). All the alkaloids were obtained from this plant for the first time.