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中文摘要：
目的探讨血管生成素1（Ang-1）及其受体Tie-2与药物流产后异常子宫出血之间的关系。方法选取40例药物流产后异常子宫出血妇女及20例药物流产后无异常出血妇女的子宫内膜，用免疫组化方法测定子宫内膜中Ang-1及其受体的表达。结果Ang-1在子宫内膜基质细胞和腺体上皮细胞、血管壁上都有表达，而Tie-2则主要表达于腺体上皮细胞和血管壁。两者在出血组的表达水平均高于对照组。但仅Ang-1表达的差异有统计学意义（P〈0．05）。结论药物流产后子宫内膜中Ang-1的异常表达可能是导致异常出血的机制之一。
英文摘要：
Objective TO investigate the expression of angiopoietin-1 （Ang-1） and Tie-2 in endometrium of woman with abnormal bleeding induced by medical abortion. Methods The expression of Ang-land Tie-2 was detected by histoimmunochemical method in endometrium of 40 women with abnormal bleeding and 20 women without bleeding after medical abortion. Results The expression levels of Ang-1 were higher in women with abnormal bleeding than those without bleeding; however there were no differences in Tie-2 expression between two groups. Conclusion The upgregulated expression of Ang- 1 indicated that it may be involved in the mechanisms of abnormal bleeding after medical abortion.
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