中文摘要：

目的：研究肺癌组织中Nrf2、Keap1和NQO1蛋白表达的情况。方法：采用免疫组化法检测67例肺癌患者的肺癌组织及癌旁正常组织中Nrf2、Keap1和NQO1蛋白的表达,并分析Keap1、Nrf2和NQO1蛋白的表达与肺癌临床病理特征的关系。结果：Keap1蛋白在肺Ⅰ、Ⅱ、Ⅲ期鳞癌和Ⅲ期、Ⅳ期腺癌中的表达高于癌旁正常组织（P〈0.05）;Nrf2蛋白在肺Ⅰ期鳞癌和Ⅱ、Ⅲ、Ⅳ期腺癌中的表达低于癌旁正常组织（P〈0.05）;NQO1蛋白在肺Ⅰ期鳞癌中的表达低于癌旁正常组织（P〈0.05）,在Ⅱ期腺癌中的表达高于癌旁正常组织（P〈0.05）。3种蛋白的表达与肺癌患者的临床分期和是否侵及胸膜有关（P〈0.05）。结论：肺癌组织中Keap1、Nrf2、NQO1蛋白表达异常,提示Keap1-Nrf2/ARE通路在肺癌的发生发展中可能发挥重要的作用。

英文摘要：

Aim：To study the protein expressions of Nrf2,Keap1 and NQO1 in lung cancer tissue.Methods：Immunohistochemistry was applied to detect the protein expressions of Keap1,Nrf2 and NQO1 in 67 cases of lung cancer tissue and adjacent normal tissue.Results：The protein expression of Keap1 was significantly higher in human phaseⅠ,Ⅱ and Ⅲ lung squamous cell carcinoma and phase Ⅲ and Ⅳ lung adenocarcinoma than normal tissue（P 〈 0.05）.The protein expression of Nrf2 was significantly lower in human phaseⅠlung squamous cell carcinoma and phase Ⅱ,Ⅲ and Ⅳ lung adenocarcinoma than normal tissue（P 〈 0.05）.The protein expression of NQO1 was significantly lower in human phaseⅠlung squamous cell carcinoma and was significantly higher in human phase Ⅱ lung adenocarcinoma than normal tissue（P 〈 0.05）.The protein expressions of Keap1,NQO1 and Nrf2 were related with clinical classification and distant metastasis（P 〈 0.05）.Conclusion：The abnormal expressions of Keap1,Nrf2,and NQO1 in lung cancer indicate that Keap1-Nrf2 /ARE pathway may play an important role in lung cancer initiation and promotion.