中文摘要：

目的：探讨外周血白细胞端粒DNA相对长度与肺癌的关系。方法：采用SYBRGreenⅠRealTimePCR方法检测54例肺癌患者（病例组）和77例健康对照（对照组）外周血白细胞端粒DNA的相对长度。结果：病例组外周血白细胞端粒DNA的相对长度为（3.43±0.87）,短于对照组（3.86±1.46）,差异有统计学意义（t=2.093,P=0.038）。进一步应用logistic回归分析,把端粒长度按百分位数P33和P66从短到长依次分为T1、T2、T3三层,调整吸烟与年龄因素后,以T3层为参考水平,结果显示T2层患肺癌危险度为3.933（95%CI1.139～13.580）,T1层患肺癌危险度为4.684（95%CI1.377～15.936）,P〈0.05。结论：端粒DNA相对长度缩短可能与肺癌的发生有关。

英文摘要：

Aim：To explore the relationship between relative telomere length in peripheral blood leukocytes and lung cancer.Methods：SYBR GreenⅠReal Time PCR was used to measure the relative telomere length in peripheral blood leukocytes of two groups including 54 lung cancer patients（case group） and 77 healthy people（control group）.Results：Therelative telomere length in peripheral blood leukocytes in case group was（3.43 ± 0.87）,which was shorter than that in control group（3.86 ± 1.46）,and there was significant difference（t = 2.093,P = 0.038）.Using logistic analysis and according to percentile（P33 and P66） to divide relative telomere length into three layers（T1,T2,T3） ;after adjusting the factors of smoking and age and using T3 as reference level,the results suggested that lung cancer risk of people with T2 relative telomere length was 3.933（95% CI 1.139 - 13.580,P 〈 0.05）,and that of people with T1 was 4.684（95% CI 1.377 - 15.936,P 〈 0.05）.Conclusion：Short relative telomere length may be related to the occurrence of lung cancer.