中文摘要：

目的通过测定中介素（IMD）、血清N末端B型脑钠肽前体（NT-pro BNP）水平改变,探讨其在老年慢性心力衰竭中的临床意义。方法根据美国纽约心脏协会（NYHA）标准将所选的老年慢性心力衰竭患者分为心功能I级组、Ⅱ级组、Ⅲ级组、Ⅳ级组,测定上述各组及正常对照组血清中的IMD、NT-pro BNP水平,并进行比较分析。结果Ⅳ级组的IMD分别低于I级和Ⅱ级组、Ⅲ级组,差异有统计学意义（P〈0.05）。Ⅲ级组的IMD水平分别低于I级和Ⅱ级组,差异有统计学意义（P〈0.05）。老年慢性心力衰竭组NT-pro BNP水平明显高于对照组（P〈0.01）,并逐级增加（P〈0.05）。IMD与NT-pro BNP呈负相关关系（r=-0.573,P〈0.001）。结论 IMD、NT-pro BNP水平改变有助于了解老年慢性心力衰竭病情程度和评估此类患者预后,而患者IMD水平越低其预后较差。

英文摘要：

Objective To measure the change of Intermedin（IMD） and N-Terminal pro-Brain Natriuretic Peptide（NT-pro BNP） so as to explore their clinical significance in diagnosis of the elderly patients with chronic heart failure（CHF）. Methods According to the American New York Heart Association（NYHA） standard, the elderly CHF patients were divided into Cardiac Function Grade I Group, Grade II Group, Grade III Group and Grade IV Group for comparative analysis. The level of serum IMD and NT-pro BNP in elderly CHF patients and the normal Control Group were measured. Results IMD of Grade IV Group was lower than that of Grade I, II Group and III Group with statistically significant difference（P〈0.05）. IMD of Grade III Group was lower than that of Grade I and II Group with statistically significant difference（P〈0.05）. The level of NT-pro BNP in CHF patients was significantly higher than the normal Control Group（P〈0.01）, and was increased following the increase of grade（P〈0.05）. The plasma levels of IMD and NT-pro BNP were negatively correlated（r=-0.573, P0. 001）. Conclusion The changes of IMD and NT-pro BNP contribute to the understanding of the severity and prognosis assessment of elderly patients with chronic heart failure. Patients＇ lower IMD indicates lower prognosis assessment.