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MCM3AP,a Novel HBV Integration Site in Hepatocellular Carcinoma and Its Implication in Hepatocarcinogenesis
  • ISSN号：1007-3418
  • 期刊名称：《中华肝脏病杂志》
  • 时间：0
  • 分类：R735.7[医药卫生—肿瘤;医药卫生—临床医学]
  • 作者机构：[1]Institute of Liver Diseases, [2]Tongji Hospital, [3]Tongji Medical College, [4]Huazhong University of Science and Technology, [5]Department of Gastroenterology
  • 相关基金：supported by grants from the National Natural Sciences Foundation of China (No. 30872237);; the National Program on Key Basic Research Project (973 Program) (No. 2007CB512900)
作者： 王晶[1], 林菊生[2], 常莹[3], 黎培元[4], 杨玉珍[5]
中文摘要：

A novel HBV integration site involved in hepatocarcinogenesis was investigated. The HBV DNA integration sites were detected by Alu-PCR in hepatocellular carcinoma tissues, matched surrounding liver tissues in 30 patients with hepatitis B-related hepatocellular carcinoma (HCC) and 3 cases of normal liver tissues. The integration sites and flanking sequences in human genome were sequenced and blasted, and the expression of integrated HBV genes was determined by reverse transcriptase-polymerase chain reaction ...

英文摘要：

A novel HBV integration site involved in hepatocarcinogenesis was investigated. The HBV DNA integration sites were detected by Alu-PCR in hepatocellular carcinoma tissues, matched surrounding liver tissues in 30 patients with hepatitis B-related hepatocellular carcinoma (HCC) and 3 cases of normal liver tissues. The integration sites and flanking sequences in human genome were sequenced and blasted, and the expression of integrated HBV genes was determined by reverse transcriptase-polymerase chain reaction ...

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期刊信息
  • 《中华肝脏病杂志》
  • 北大核心期刊（2011版）
  • 主管单位:中国科学技术协会
  • 主办单位:中华医学会
  • 主编：
  • 地址：重庆市渝中区临江路74号
  • 邮编：400010
  • 邮箱：chnhepa@online.cq.cn
  • 电话：023-63706512
  • 国际标准刊号：ISSN：1007-3418
  • 国内统一刊号：ISSN：50-1113/R
  • 邮发代号:78-56
  • 获奖情况:
  • 中国期刊方阵“双效”期刊
  • 国内外数据库收录:
  • 美国化学文摘（网络版）,荷兰文摘与引文数据库,美国生物医学检索系统,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊（2004版）,中国北大核心期刊（2008版）,中国北大核心期刊（2011版）,中国北大核心期刊（2014版）
  • 被引量:47128