中文摘要：

目的：探讨利用四维超声的时间一空间相关技术（STIC）辅助诊断中孕期胎儿室间隔缺损（VSD）的应用价值。方法：对2326例中孕期（孕21-28周）的胎儿先进行常规超声心动图检查，然后所有胎儿均加用STIC技术检查胎儿心脏。对比常规超声心动图与STIC技术的诊断差异。结果：2326例胎儿中仅有35例STIC图像不合格。产后确诊VSD28例，所有VSD病例STIC均图像合格。超声心动图诊断20例（敏感度71．4％），STIC技术诊断27例（敏感度96．4％），STIC与超声心动图比较差别有统计学意义（P〈0．05）。结论：孕21－28周的中孕期胎儿是STIC采集容积数据的理想时期。STIC技术能提供VSD较心动图更多的影像信息，STIC辅助超声心动图可以提高VSD的诊断率，具有重要的临床意义。

英文摘要：

Purpose： To explore the clinical value of spatio-temporal image correlation（STIC） in diagnosing ventricular septal defect in second trimester. Methods： Two thousand three hundred and twenty-six fetuses in second trimester （pregnant 21 weeks -28 weeks） were examined by routine echocardiography, and then with STIC. The difference of diagnosis between that made by routine echocardiography and by echocardiography with STIC was compared. Results： Of 2326 cases, fetal STIC imaging was failed in 35 cases. Of all the patients diagnosed as VSD, 28 cases were diagnosed after birth. The fetal STIC imagings of them were success. Twenty cases were diagnosed by routine echocardiography （rate of sensitivity 71.4%）, 27 cases were by STIC （rate of sensitivity 96.4%）. There was significant difference between the diagnosis rate made by routine echocardiography and STIC （P〈0.05）. Conclusion： Second trimester is the ideal time for STIC imaging. STIC can provide more image information of VSD. It can improve the diagnosis rate of VSD. As a supplementary mean to routine echocardiography, it has important clinical significance.